Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development

SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation cau...

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Autores principales:	Jeremie Vitte, Fuying Gao, Giovanni Coppola, Alexander R. Judkins, Marco Giovannini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1faf2971b5a4423bb8a856e7f90310eb
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spelling	oai:doaj.org-article:1faf2971b5a4423bb8a856e7f90310eb2021-12-02T13:57:55ZTiming of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development10.1038/s41467-017-00346-52041-1723https://doaj.org/article/1faf2971b5a4423bb8a856e7f90310eb2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00346-5https://doaj.org/toc/2041-1723SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation causes shwannomas.Jeremie VitteFuying GaoGiovanni CoppolaAlexander R. JudkinsMarco GiovanniniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeremie Vitte Fuying Gao Giovanni Coppola Alexander R. Judkins Marco Giovannini Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
description	SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation causes shwannomas.
format	article
author	Jeremie Vitte Fuying Gao Giovanni Coppola Alexander R. Judkins Marco Giovannini
author_facet	Jeremie Vitte Fuying Gao Giovanni Coppola Alexander R. Judkins Marco Giovannini
author_sort	Jeremie Vitte
title	Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
title_short	Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
title_full	Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
title_fullStr	Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
title_full_unstemmed	Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
title_sort	timing of smarcb1 and nf2 inactivation determines schwannoma versus rhabdoid tumor development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1faf2971b5a4423bb8a856e7f90310eb
work_keys_str_mv	AT jeremievitte timingofsmarcb1andnf2inactivationdeterminesschwannomaversusrhabdoidtumordevelopment AT fuyinggao timingofsmarcb1andnf2inactivationdeterminesschwannomaversusrhabdoidtumordevelopment AT giovannicoppola timingofsmarcb1andnf2inactivationdeterminesschwannomaversusrhabdoidtumordevelopment AT alexanderrjudkins timingofsmarcb1andnf2inactivationdeterminesschwannomaversusrhabdoidtumordevelopment AT marcogiovannini timingofsmarcb1andnf2inactivationdeterminesschwannomaversusrhabdoidtumordevelopment
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Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development

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