Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation cau...
Guardado en:
Autores principales: | Jeremie Vitte, Fuying Gao, Giovanni Coppola, Alexander R. Judkins, Marco Giovannini |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/1faf2971b5a4423bb8a856e7f90310eb |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation
por: Zhi-Yan Han, et al.
Publicado: (2016) -
SMARCB1(INI1)-deficient undifferentiated carcinoma with rhabdoid features of anorectal origin
por: Hanan Dihowm, et al.
Publicado: (2021) -
SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression
por: Tara T. Doucet-O’Hare, et al.
Publicado: (2021) -
Inhibition of MYC by the SMARCB1 tumor suppressor
por: April M. Weissmiller, et al.
Publicado: (2019) -
Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors
por: Martin Ebinger, et al.
Publicado: (2021)