Towards precision in defining COPD exacerbations

COPD is the most prevalent chronic respiratory disease worldwide and a major cause of disability and death. Acute exacerbations of COPD remain a key feature of the disease in many patients and research assessing interventions to prevent and treat them requires a robust definition with high sensitivi...

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Autor principal:	Christine R. Jenkins
Formato:	article
Lenguaje:	EN
Publicado:	European Respiratory Society 2021
Materias:	Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/1fb105f0f96f4c49b880ccfe41317e1f
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spelling	oai:doaj.org-article:1fb105f0f96f4c49b880ccfe41317e1f2021-11-24T07:45:28ZTowards precision in defining COPD exacerbations1810-68382073-473510.1183/20734735.0081-2021https://doaj.org/article/1fb105f0f96f4c49b880ccfe41317e1f2021-09-01T00:00:00Zhttp://breathe.ersjournals.com/content/17/3/210081.fullhttps://doaj.org/toc/1810-6838https://doaj.org/toc/2073-4735COPD is the most prevalent chronic respiratory disease worldwide and a major cause of disability and death. Acute exacerbations of COPD remain a key feature of the disease in many patients and research assessing interventions to prevent and treat them requires a robust definition with high sensitivity and specificity. To date, no such definition exists, and multiple different definitions are used in clinical studies depending on the research question. The strengths and weaknesses of current definitions are discussed in the context of evolving knowledge and different settings in which studies are undertaken. Whether identification and recording of exacerbations remains essentially clinical, or can be identified with a dependable biomarker, it should be sensitive and adaptable to context while retaining clarity and facilitating data collection. This is essential to progress a better understanding of the pathophysiology and phenotypic expression of exacerbations to reduce their impact and personal burden for patients.Christine R. JenkinsEuropean Respiratory SocietyarticleDiseases of the respiratory systemRC705-779ENBreathe, Vol 17, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the respiratory system RC705-779
spellingShingle	Diseases of the respiratory system RC705-779 Christine R. Jenkins Towards precision in defining COPD exacerbations
description	COPD is the most prevalent chronic respiratory disease worldwide and a major cause of disability and death. Acute exacerbations of COPD remain a key feature of the disease in many patients and research assessing interventions to prevent and treat them requires a robust definition with high sensitivity and specificity. To date, no such definition exists, and multiple different definitions are used in clinical studies depending on the research question. The strengths and weaknesses of current definitions are discussed in the context of evolving knowledge and different settings in which studies are undertaken. Whether identification and recording of exacerbations remains essentially clinical, or can be identified with a dependable biomarker, it should be sensitive and adaptable to context while retaining clarity and facilitating data collection. This is essential to progress a better understanding of the pathophysiology and phenotypic expression of exacerbations to reduce their impact and personal burden for patients.
format	article
author	Christine R. Jenkins
author_facet	Christine R. Jenkins
author_sort	Christine R. Jenkins
title	Towards precision in defining COPD exacerbations
title_short	Towards precision in defining COPD exacerbations
title_full	Towards precision in defining COPD exacerbations
title_fullStr	Towards precision in defining COPD exacerbations
title_full_unstemmed	Towards precision in defining COPD exacerbations
title_sort	towards precision in defining copd exacerbations
publisher	European Respiratory Society
publishDate	2021
url	https://doaj.org/article/1fb105f0f96f4c49b880ccfe41317e1f
work_keys_str_mv	AT christinerjenkins towardsprecisionindefiningcopdexacerbations
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Towards precision in defining COPD exacerbations

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