Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Tumour initiating cells (TICs) are anoikis resistant in suspension culture and they are critical for initiating tumorigenesis in vivo. Here, the authors show that these features are promoted by hemidesmosome-like structures enriched in laminin V and collagen XVII 5 upregulated in TICs by phospho-STA...

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Autores principales:	Chen-Chi Liu, Shih-Pei Lin, Han-Shui Hsu, Shung-Haur Yang, Chiu-Hua Lin, Muh-Hwa Yang, Mien-Chie Hung, Shih-Chieh Hung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fb2f33bef81497c98fd83288db8f8b0
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spelling	oai:doaj.org-article:1fb2f33bef81497c98fd83288db8f8b02021-12-02T15:35:23ZSuspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells10.1038/ncomms117982041-1723https://doaj.org/article/1fb2f33bef81497c98fd83288db8f8b02016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11798https://doaj.org/toc/2041-1723Tumour initiating cells (TICs) are anoikis resistant in suspension culture and they are critical for initiating tumorigenesis in vivo. Here, the authors show that these features are promoted by hemidesmosome-like structures enriched in laminin V and collagen XVII 5 upregulated in TICs by phospho-STAT3 whose levels are increased through PP2A inactivation.Chen-Chi LiuShih-Pei LinHan-Shui HsuShung-Haur YangChiu-Hua LinMuh-Hwa YangMien-Chie HungShih-Chieh HungNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen-Chi Liu Shih-Pei Lin Han-Shui Hsu Shung-Haur Yang Chiu-Hua Lin Muh-Hwa Yang Mien-Chie Hung Shih-Chieh Hung Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
description	Tumour initiating cells (TICs) are anoikis resistant in suspension culture and they are critical for initiating tumorigenesis in vivo. Here, the authors show that these features are promoted by hemidesmosome-like structures enriched in laminin V and collagen XVII 5 upregulated in TICs by phospho-STAT3 whose levels are increased through PP2A inactivation.
format	article
author	Chen-Chi Liu Shih-Pei Lin Han-Shui Hsu Shung-Haur Yang Chiu-Hua Lin Muh-Hwa Yang Mien-Chie Hung Shih-Chieh Hung
author_facet	Chen-Chi Liu Shih-Pei Lin Han-Shui Hsu Shung-Haur Yang Chiu-Hua Lin Muh-Hwa Yang Mien-Chie Hung Shih-Chieh Hung
author_sort	Chen-Chi Liu
title	Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
title_short	Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
title_full	Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
title_fullStr	Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
title_full_unstemmed	Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
title_sort	suspension survival mediated by pp2a-stat3-col xvii determines tumour initiation and metastasis in cancer stem cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1fb2f33bef81497c98fd83288db8f8b0
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Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

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