Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Tumour initiating cells (TICs) are anoikis resistant in suspension culture and they are critical for initiating tumorigenesis in vivo. Here, the authors show that these features are promoted by hemidesmosome-like structures enriched in laminin V and collagen XVII 5 upregulated in TICs by phospho-STA...

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Autores principales: Chen-Chi Liu, Shih-Pei Lin, Han-Shui Hsu, Shung-Haur Yang, Chiu-Hua Lin, Muh-Hwa Yang, Mien-Chie Hung, Shih-Chieh Hung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/1fb2f33bef81497c98fd83288db8f8b0
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