Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

Glioma can originate from the transformation of neural progenitor cells into glioma initiating cells. Here, the authors demonstrate the use of induced pluripotent stem cells as a suitable model for generating neural progenitor cells, which can be subsequently transformed to glioma initiating cells t...

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Autores principales:	Ignacio Sancho-Martinez, Emmanuel Nivet, Yun Xia, Tomoaki Hishida, Aitor Aguirre, Alejandro Ocampo, Li Ma, Robert Morey, Marie N. Krause, Andreas Zembrzycki, Olaf Ansorge, Eric Vazquez-Ferrer, Ilir Dubova, Pradeep Reddy, David Lam, Yuriko Hishida, Min-Zu Wu, Concepcion Rodriguez Esteban, Dennis O’Leary, Geoffrey M. Wahl, Inder M. Verma, Louise C. Laurent, Juan Carlos Izpisua Belmonte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fb354a0ffc8422d8d9d844eb2315537
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spelling	oai:doaj.org-article:1fb354a0ffc8422d8d9d844eb23155372021-12-02T16:58:12ZEstablishment of human iPSC-based models for the study and targeting of glioma initiating cells10.1038/ncomms107432041-1723https://doaj.org/article/1fb354a0ffc8422d8d9d844eb23155372016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10743https://doaj.org/toc/2041-1723Glioma can originate from the transformation of neural progenitor cells into glioma initiating cells. Here, the authors demonstrate the use of induced pluripotent stem cells as a suitable model for generating neural progenitor cells, which can be subsequently transformed to glioma initiating cells that are able to the generate human glioma-like tumours in mice.Ignacio Sancho-MartinezEmmanuel NivetYun XiaTomoaki HishidaAitor AguirreAlejandro OcampoLi MaRobert MoreyMarie N. KrauseAndreas ZembrzyckiOlaf AnsorgeEric Vazquez-FerrerIlir DubovaPradeep ReddyDavid LamYuriko HishidaMin-Zu WuConcepcion Rodriguez EstebanDennis O’LearyGeoffrey M. WahlInder M. VermaLouise C. LaurentJuan Carlos Izpisua BelmonteNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ignacio Sancho-Martinez Emmanuel Nivet Yun Xia Tomoaki Hishida Aitor Aguirre Alejandro Ocampo Li Ma Robert Morey Marie N. Krause Andreas Zembrzycki Olaf Ansorge Eric Vazquez-Ferrer Ilir Dubova Pradeep Reddy David Lam Yuriko Hishida Min-Zu Wu Concepcion Rodriguez Esteban Dennis O’Leary Geoffrey M. Wahl Inder M. Verma Louise C. Laurent Juan Carlos Izpisua Belmonte Establishment of human iPSC-based models for the study and targeting of glioma initiating cells
description	Glioma can originate from the transformation of neural progenitor cells into glioma initiating cells. Here, the authors demonstrate the use of induced pluripotent stem cells as a suitable model for generating neural progenitor cells, which can be subsequently transformed to glioma initiating cells that are able to the generate human glioma-like tumours in mice.
format	article
author	Ignacio Sancho-Martinez Emmanuel Nivet Yun Xia Tomoaki Hishida Aitor Aguirre Alejandro Ocampo Li Ma Robert Morey Marie N. Krause Andreas Zembrzycki Olaf Ansorge Eric Vazquez-Ferrer Ilir Dubova Pradeep Reddy David Lam Yuriko Hishida Min-Zu Wu Concepcion Rodriguez Esteban Dennis O’Leary Geoffrey M. Wahl Inder M. Verma Louise C. Laurent Juan Carlos Izpisua Belmonte
author_facet	Ignacio Sancho-Martinez Emmanuel Nivet Yun Xia Tomoaki Hishida Aitor Aguirre Alejandro Ocampo Li Ma Robert Morey Marie N. Krause Andreas Zembrzycki Olaf Ansorge Eric Vazquez-Ferrer Ilir Dubova Pradeep Reddy David Lam Yuriko Hishida Min-Zu Wu Concepcion Rodriguez Esteban Dennis O’Leary Geoffrey M. Wahl Inder M. Verma Louise C. Laurent Juan Carlos Izpisua Belmonte
author_sort	Ignacio Sancho-Martinez
title	Establishment of human iPSC-based models for the study and targeting of glioma initiating cells
title_short	Establishment of human iPSC-based models for the study and targeting of glioma initiating cells
title_full	Establishment of human iPSC-based models for the study and targeting of glioma initiating cells
title_fullStr	Establishment of human iPSC-based models for the study and targeting of glioma initiating cells
title_full_unstemmed	Establishment of human iPSC-based models for the study and targeting of glioma initiating cells
title_sort	establishment of human ipsc-based models for the study and targeting of glioma initiating cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1fb354a0ffc8422d8d9d844eb2315537
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Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

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