Associations between malaria in pregnancy and neonatal neurological outcomes

Objective: To compare neurological functioning of neonates born to mothers with and without malaria in pregnancy. Methods: Pregnant women presenting at Korle Bu Teaching Hospital, Ghana were recruited into this prospective observational study. Malaria exposure was determined by clinically documented...

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Autores principales:	Harriet L.S. Lawford, Mercy A. Nuamah, Helen G. Liley, Alison Griffin, Cecilia E. Lekpor, Felix Botchway, Samuel A. Oppong, Ali Samba, Ebenezer V. Badoe, Sailesh Kumar, Anne CC Lee, Richard K. Gyasi, Andrew A. Adjei, Samudragupta Bora
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Brain Infant Malaria Neurodevelopment Sub-Saharan Africa Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/1fb57fee8097470a9ac50f25b4fd5286
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spelling	oai:doaj.org-article:1fb57fee8097470a9ac50f25b4fd52862021-11-30T04:13:59ZAssociations between malaria in pregnancy and neonatal neurological outcomes1201-971210.1016/j.ijid.2021.07.037https://doaj.org/article/1fb57fee8097470a9ac50f25b4fd52862021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221005932https://doaj.org/toc/1201-9712Objective: To compare neurological functioning of neonates born to mothers with and without malaria in pregnancy. Methods: Pregnant women presenting at Korle Bu Teaching Hospital, Ghana were recruited into this prospective observational study. Malaria exposure was determined by clinically documented antenatal malaria infection; parasitemia in maternal, placental, or umbilical cord blood; or placental histology. Neurological functioning was assessed using the Hammersmith Neonatal Neurological Examination within 48 hours of birth. Performance was classified as ''optimal'' or ''suboptimal'' by subdomain and overall. Results: Between November 21, 2018 and February 10, 2019, a total of 211 term-born neonates, of whom 27 (13%) were exposed to malaria in pregnancy, were included. In the reflexes subdomain, exposed neonates tended to score lower (adjusted mean difference -0.34, 95% confidence interval -0.70 to 0.03), with an increased risk (adjusted risk ratio 1.63, 95% confidence interval 1.09 to 2.44) of suboptimal performance compared with unexposed neonates. There were no significant between-group differences in scores or optimality classification for the remaining subdomains and overall. Conclusions: Malaria-exposed neonates had similar neurological functioning relative to unexposed neonates, with differences confined to the reflexes subdomain, suggesting potential underlying neurological immaturity or injury. Further studies are needed to confirm these findings and determine the significance of malaria in pregnancy on long-term neurological outcomes.Harriet L.S. LawfordMercy A. NuamahHelen G. LileyAlison GriffinCecilia E. LekporFelix BotchwaySamuel A. OppongAli SambaEbenezer V. BadoeSailesh KumarAnne CC LeeRichard K. GyasiAndrew A. AdjeiSamudragupta BoraElsevierarticleBrainInfantMalariaNeurodevelopmentSub-Saharan AfricaInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 144-151 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Brain Infant Malaria Neurodevelopment Sub-Saharan Africa Infectious and parasitic diseases RC109-216
spellingShingle	Brain Infant Malaria Neurodevelopment Sub-Saharan Africa Infectious and parasitic diseases RC109-216 Harriet L.S. Lawford Mercy A. Nuamah Helen G. Liley Alison Griffin Cecilia E. Lekpor Felix Botchway Samuel A. Oppong Ali Samba Ebenezer V. Badoe Sailesh Kumar Anne CC Lee Richard K. Gyasi Andrew A. Adjei Samudragupta Bora Associations between malaria in pregnancy and neonatal neurological outcomes
description	Objective: To compare neurological functioning of neonates born to mothers with and without malaria in pregnancy. Methods: Pregnant women presenting at Korle Bu Teaching Hospital, Ghana were recruited into this prospective observational study. Malaria exposure was determined by clinically documented antenatal malaria infection; parasitemia in maternal, placental, or umbilical cord blood; or placental histology. Neurological functioning was assessed using the Hammersmith Neonatal Neurological Examination within 48 hours of birth. Performance was classified as ''optimal'' or ''suboptimal'' by subdomain and overall. Results: Between November 21, 2018 and February 10, 2019, a total of 211 term-born neonates, of whom 27 (13%) were exposed to malaria in pregnancy, were included. In the reflexes subdomain, exposed neonates tended to score lower (adjusted mean difference -0.34, 95% confidence interval -0.70 to 0.03), with an increased risk (adjusted risk ratio 1.63, 95% confidence interval 1.09 to 2.44) of suboptimal performance compared with unexposed neonates. There were no significant between-group differences in scores or optimality classification for the remaining subdomains and overall. Conclusions: Malaria-exposed neonates had similar neurological functioning relative to unexposed neonates, with differences confined to the reflexes subdomain, suggesting potential underlying neurological immaturity or injury. Further studies are needed to confirm these findings and determine the significance of malaria in pregnancy on long-term neurological outcomes.
format	article
author	Harriet L.S. Lawford Mercy A. Nuamah Helen G. Liley Alison Griffin Cecilia E. Lekpor Felix Botchway Samuel A. Oppong Ali Samba Ebenezer V. Badoe Sailesh Kumar Anne CC Lee Richard K. Gyasi Andrew A. Adjei Samudragupta Bora
author_facet	Harriet L.S. Lawford Mercy A. Nuamah Helen G. Liley Alison Griffin Cecilia E. Lekpor Felix Botchway Samuel A. Oppong Ali Samba Ebenezer V. Badoe Sailesh Kumar Anne CC Lee Richard K. Gyasi Andrew A. Adjei Samudragupta Bora
author_sort	Harriet L.S. Lawford
title	Associations between malaria in pregnancy and neonatal neurological outcomes
title_short	Associations between malaria in pregnancy and neonatal neurological outcomes
title_full	Associations between malaria in pregnancy and neonatal neurological outcomes
title_fullStr	Associations between malaria in pregnancy and neonatal neurological outcomes
title_full_unstemmed	Associations between malaria in pregnancy and neonatal neurological outcomes
title_sort	associations between malaria in pregnancy and neonatal neurological outcomes
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1fb57fee8097470a9ac50f25b4fd5286
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Associations between malaria in pregnancy and neonatal neurological outcomes

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