Taste Receptors: The Gatekeepers of the Airway Epithelium

Taste receptors are well known for their role in the sensation of taste. Surprisingly, the expression and involvement of taste receptors in chemosensory processes outside the tongue have been recently identified in many organs including the airways. Currently, a clear understanding of the airway-spe...

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Autores principales:	Katleen Martens, Brecht Steelant, Dominique M. A. Bullens
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	taste receptors respiratory tract chronic airway diseases polymorphisms Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1fb645b30ad74898b79381dcb3614c4e
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spelling	oai:doaj.org-article:1fb645b30ad74898b79381dcb3614c4e2021-11-25T17:08:37ZTaste Receptors: The Gatekeepers of the Airway Epithelium10.3390/cells101128892073-4409https://doaj.org/article/1fb645b30ad74898b79381dcb3614c4e2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2889https://doaj.org/toc/2073-4409Taste receptors are well known for their role in the sensation of taste. Surprisingly, the expression and involvement of taste receptors in chemosensory processes outside the tongue have been recently identified in many organs including the airways. Currently, a clear understanding of the airway-specific function of these receptors and the endogenous activating/inhibitory ligands is lagging. The focus of this review is on recent physiological and clinical data describing the taste receptors in the airways and their activation by secreted bacterial compounds. Taste receptors in the airways are potentially involved in three different immune pathways (i.e., the production of nitric oxide and antimicrobial peptides secretion, modulation of ciliary beat frequency, and bronchial smooth muscle cell relaxation). Moreover, genetic polymorphisms in these receptors may alter the patients’ susceptibility to certain types of respiratory infections as well as to differential outcomes in patients with chronic inflammatory airway diseases such as chronic rhinosinusitis and asthma. A better understanding of the function of taste receptors in the airways may lead to the development of a novel class of therapeutic molecules that can stimulate airway mucosal immune responses and could treat patients with chronic airway diseases.Katleen MartensBrecht SteelantDominique M. A. BullensMDPI AGarticletaste receptorsrespiratory tractchronic airway diseasespolymorphismsBiology (General)QH301-705.5ENCells, Vol 10, Iss 2889, p 2889 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	taste receptors respiratory tract chronic airway diseases polymorphisms Biology (General) QH301-705.5
spellingShingle	taste receptors respiratory tract chronic airway diseases polymorphisms Biology (General) QH301-705.5 Katleen Martens Brecht Steelant Dominique M. A. Bullens Taste Receptors: The Gatekeepers of the Airway Epithelium
description	Taste receptors are well known for their role in the sensation of taste. Surprisingly, the expression and involvement of taste receptors in chemosensory processes outside the tongue have been recently identified in many organs including the airways. Currently, a clear understanding of the airway-specific function of these receptors and the endogenous activating/inhibitory ligands is lagging. The focus of this review is on recent physiological and clinical data describing the taste receptors in the airways and their activation by secreted bacterial compounds. Taste receptors in the airways are potentially involved in three different immune pathways (i.e., the production of nitric oxide and antimicrobial peptides secretion, modulation of ciliary beat frequency, and bronchial smooth muscle cell relaxation). Moreover, genetic polymorphisms in these receptors may alter the patients’ susceptibility to certain types of respiratory infections as well as to differential outcomes in patients with chronic inflammatory airway diseases such as chronic rhinosinusitis and asthma. A better understanding of the function of taste receptors in the airways may lead to the development of a novel class of therapeutic molecules that can stimulate airway mucosal immune responses and could treat patients with chronic airway diseases.
format	article
author	Katleen Martens Brecht Steelant Dominique M. A. Bullens
author_facet	Katleen Martens Brecht Steelant Dominique M. A. Bullens
author_sort	Katleen Martens
title	Taste Receptors: The Gatekeepers of the Airway Epithelium
title_short	Taste Receptors: The Gatekeepers of the Airway Epithelium
title_full	Taste Receptors: The Gatekeepers of the Airway Epithelium
title_fullStr	Taste Receptors: The Gatekeepers of the Airway Epithelium
title_full_unstemmed	Taste Receptors: The Gatekeepers of the Airway Epithelium
title_sort	taste receptors: the gatekeepers of the airway epithelium
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1fb645b30ad74898b79381dcb3614c4e
work_keys_str_mv	AT katleenmartens tastereceptorsthegatekeepersoftheairwayepithelium AT brechtsteelant tastereceptorsthegatekeepersoftheairwayepithelium AT dominiquemabullens tastereceptorsthegatekeepersoftheairwayepithelium
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Taste Receptors: The Gatekeepers of the Airway Epithelium

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