DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small-cell lung cancer

Objective: The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non–small-cell lung cancer (NSCLC) and compared the finding...

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Autores principales:	Xin (Eric) Jiang, Ting Xu, Qingyi Wei, Peng Li, Daniel R. Gomez, Laurence E. Court, Zhongxing Liao
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1fb70dc4e4e14ad0a9b19ac5706fdca9
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spelling	oai:doaj.org-article:1fb70dc4e4e14ad0a9b19ac5706fdca92021-12-02T12:04:38ZDNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small-cell lung cancer2095-882X10.1016/j.cdtm.2018.05.003https://doaj.org/article/1fb70dc4e4e14ad0a9b19ac5706fdca92018-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X17300932https://doaj.org/toc/2095-882XObjective: The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non–small-cell lung cancer (NSCLC) and compared the findings with the maximum standardized uptake value (SUVmax) on18F-fluorodeoxyglucose positron emission tomography (FDG PET) after (chemo)radiation therapy. Methods: This study included 151 patients with stage IA-IV NSCLC who had FDG PET at a single institution and donated blood samples before chemotherapy. We assessed the correlation of DRC, measured in peripheral T lymphocytes by a host-cell reactivation assay with SUVmax and their associations with overall survival (OS) time by hazards ratios calculated with a Cox proportional hazards regression model. Results: SUVmax of the primary tumor at diagnosis was inversely associated with lymphocyte DRC (r = −0.175, P = 0.032), particularly among patients with advanced disease (r = −0.218, P = 0.015). However, ΔSUVmax of primary tumor was not significantly associated with DRC (r = 0.005, P = 0.968). SUVmax of regional lymph nodes at diagnosis (r = −0.307, P = 0.0008) and after (chemo)radiation treatment (r = −0.329, P = 0.034) and SUVmax of the primary tumor after (chemo)radiation treatment (r = −0.253, P = 0.045) were also inversely associated with OS time. Conclusion: DRC was inversely associated with primary tumor SUVmax before treatment but not with ΔSUVmax after (chemo)radiation. Keywords: DNA repair capacity, Standardized uptake value, 18F-fluorodeoxyglucose positron emission tomography, Outcome, Non–small-cell lung cancerXin (Eric) JiangTing XuQingyi WeiPeng LiDaniel R. GomezLaurence E. CourtZhongxing LiaoKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 4, Iss 2, Pp 109-116 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xin (Eric) Jiang Ting Xu Qingyi Wei Peng Li Daniel R. Gomez Laurence E. Court Zhongxing Liao DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small-cell lung cancer
description	Objective: The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non–small-cell lung cancer (NSCLC) and compared the findings with the maximum standardized uptake value (SUVmax) on18F-fluorodeoxyglucose positron emission tomography (FDG PET) after (chemo)radiation therapy. Methods: This study included 151 patients with stage IA-IV NSCLC who had FDG PET at a single institution and donated blood samples before chemotherapy. We assessed the correlation of DRC, measured in peripheral T lymphocytes by a host-cell reactivation assay with SUVmax and their associations with overall survival (OS) time by hazards ratios calculated with a Cox proportional hazards regression model. Results: SUVmax of the primary tumor at diagnosis was inversely associated with lymphocyte DRC (r = −0.175, P = 0.032), particularly among patients with advanced disease (r = −0.218, P = 0.015). However, ΔSUVmax of primary tumor was not significantly associated with DRC (r = 0.005, P = 0.968). SUVmax of regional lymph nodes at diagnosis (r = −0.307, P = 0.0008) and after (chemo)radiation treatment (r = −0.329, P = 0.034) and SUVmax of the primary tumor after (chemo)radiation treatment (r = −0.253, P = 0.045) were also inversely associated with OS time. Conclusion: DRC was inversely associated with primary tumor SUVmax before treatment but not with ΔSUVmax after (chemo)radiation. Keywords: DNA repair capacity, Standardized uptake value, 18F-fluorodeoxyglucose positron emission tomography, Outcome, Non–small-cell lung cancer
format	article
author	Xin (Eric) Jiang Ting Xu Qingyi Wei Peng Li Daniel R. Gomez Laurence E. Court Zhongxing Liao
author_facet	Xin (Eric) Jiang Ting Xu Qingyi Wei Peng Li Daniel R. Gomez Laurence E. Court Zhongxing Liao
author_sort	Xin (Eric) Jiang
title	DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small-cell lung cancer
title_short	DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small-cell lung cancer
title_full	DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small-cell lung cancer
title_fullStr	DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small-cell lung cancer
title_full_unstemmed	DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small-cell lung cancer
title_sort	dna repair capacity correlates with standardized uptake values from 18f-fluorodeoxyglucose positron emission tomography/ct in patients with advanced non–small-cell lung cancer
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/1fb70dc4e4e14ad0a9b19ac5706fdca9
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DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small-cell lung cancer

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