Phakic Intraocular Lens Implantation After Deep Anterior Lamellar Keratoplasty: Retrospective Case Series Analysis With Long-Term Follow-Up

Luísa Malheiro,1 João Coelho,1 Miguel Mesquita Neves,1,2 Miguel Gomes,1,2 Luís Oliveira1,2 1Ophthalmology Department, Hospital De Santo António, Centro Hospitalar Universitário Do Porto, Porto, Portugal; 2Corneal Transplant Unit, Hospital De San...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Malheiro L, Coelho J, Neves MM, Gomes M, Oliveira L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Phakic intraocular lens Deep anterior lamellar keratoplasty Endothelial cell density visual/refractive outcomes Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1fb801602d624fe9aa5dfa95d918529f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1fb801602d624fe9aa5dfa95d918529f
record_format	dspace
spelling	oai:doaj.org-article:1fb801602d624fe9aa5dfa95d918529f2021-12-02T09:46:37ZPhakic Intraocular Lens Implantation After Deep Anterior Lamellar Keratoplasty: Retrospective Case Series Analysis With Long-Term Follow-Up1177-5483https://doaj.org/article/1fb801602d624fe9aa5dfa95d918529f2019-10-01T00:00:00Zhttps://www.dovepress.com/phakic-intraocular-lens-implantation-after-deep-anterior-lamellar-kera-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Luísa Malheiro,1 João Coelho,1 Miguel Mesquita Neves,1,2 Miguel Gomes,1,2 Luís Oliveira1,2 1Ophthalmology Department, Hospital De Santo António, Centro Hospitalar Universitário Do Porto, Porto, Portugal; 2Corneal Transplant Unit, Hospital De Santo António, Centro Hospitalar Universitário Do Porto, Porto, PortugalCorrespondence: Luísa MalheiroOphthalmology Department, Hospital de Santo António, Centro Hospitalar Universitário do Porto, Porto 4099-001, PortugalTel +351918558414Email luisamalheiro90@gmail.comPurpose: To report outcomes of phakic intraocular lens (IOL) implantation after deep anterior lamellar keratoplasty (DALK) to correct high ametropia.Setting: Centro Hospitalar Universitário do Porto, Portugal.Methods: Retrospective case series with 11 eyes submitted to phakic IOL implantation after DALK. Main outcomes measured were uncorrected and corrected distance visual acuity (UDVA and CDVA), refractive error components, tomographic parameters and endothelial cell density (ECD). The minimum follow-up was 3 years for all cases.Results: Mean ECD loss was 8.7±6.7% at 1 year, 13.1±8.6% at 3 years (n=11; p=0.016, p=0.007, respectively) and 14.0±20.4% at 5 years (n=5, p=0.212). Mean logMAR UDVA increased from 1.27±0.90logMAR preoperatively to 0.16±0.15logMAR postoperatively (p≤0.001) and no statistically significant differences were registered during follow-up. All patients gained at least 5 lines of UDVA. 54.5% of the eyes gained 1 line in CDVA postoperative and only one eye lost one CDVA line through follow-up. Efficacy and safety indexes at 1 and 3 years were 1.01–0.97 and 1.24–1.21, respectively. Mean spherical equivalent was reduced from −7.84±4.63 D preoperatively to −1.05±1.07 D postoperatively (p=0.001). Mean percentage of reduction in refractive cylinder and spherical error was 83.8±15.8% and 73.1±31.5%, respectively, p≤0.001 for both. In one eye there was a significantly gradual ECD loss over 5 years follow-up and the patient will be submitted to IOL explant.Conclusion: Phakic IOLs were effective for correction high ametropia after DALK, showing high efficacy and safety indexes with stability over time. However, it was registered a continuing endothelial cell loss postoperatively, which assumed to be higher than those reported in eyes without DALK.Keywords: phakic intraocular lens, deep anterior lamellar keratoplasty, endothelial cell density, visual outcomes, refractive outcomesMalheiro LCoelho JNeves MMGomes MOliveira LDove Medical PressarticlePhakic intraocular lensDeep anterior lamellar keratoplastyEndothelial cell densityvisual/refractive outcomesOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2043-2052 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Phakic intraocular lens Deep anterior lamellar keratoplasty Endothelial cell density visual/refractive outcomes Ophthalmology RE1-994
spellingShingle	Phakic intraocular lens Deep anterior lamellar keratoplasty Endothelial cell density visual/refractive outcomes Ophthalmology RE1-994 Malheiro L Coelho J Neves MM Gomes M Oliveira L Phakic Intraocular Lens Implantation After Deep Anterior Lamellar Keratoplasty: Retrospective Case Series Analysis With Long-Term Follow-Up
description	Luísa Malheiro,1 João Coelho,1 Miguel Mesquita Neves,1,2 Miguel Gomes,1,2 Luís Oliveira1,2 1Ophthalmology Department, Hospital De Santo António, Centro Hospitalar Universitário Do Porto, Porto, Portugal; 2Corneal Transplant Unit, Hospital De Santo António, Centro Hospitalar Universitário Do Porto, Porto, PortugalCorrespondence: Luísa MalheiroOphthalmology Department, Hospital de Santo António, Centro Hospitalar Universitário do Porto, Porto 4099-001, PortugalTel +351918558414Email luisamalheiro90@gmail.comPurpose: To report outcomes of phakic intraocular lens (IOL) implantation after deep anterior lamellar keratoplasty (DALK) to correct high ametropia.Setting: Centro Hospitalar Universitário do Porto, Portugal.Methods: Retrospective case series with 11 eyes submitted to phakic IOL implantation after DALK. Main outcomes measured were uncorrected and corrected distance visual acuity (UDVA and CDVA), refractive error components, tomographic parameters and endothelial cell density (ECD). The minimum follow-up was 3 years for all cases.Results: Mean ECD loss was 8.7±6.7% at 1 year, 13.1±8.6% at 3 years (n=11; p=0.016, p=0.007, respectively) and 14.0±20.4% at 5 years (n=5, p=0.212). Mean logMAR UDVA increased from 1.27±0.90logMAR preoperatively to 0.16±0.15logMAR postoperatively (p≤0.001) and no statistically significant differences were registered during follow-up. All patients gained at least 5 lines of UDVA. 54.5% of the eyes gained 1 line in CDVA postoperative and only one eye lost one CDVA line through follow-up. Efficacy and safety indexes at 1 and 3 years were 1.01–0.97 and 1.24–1.21, respectively. Mean spherical equivalent was reduced from −7.84±4.63 D preoperatively to −1.05±1.07 D postoperatively (p=0.001). Mean percentage of reduction in refractive cylinder and spherical error was 83.8±15.8% and 73.1±31.5%, respectively, p≤0.001 for both. In one eye there was a significantly gradual ECD loss over 5 years follow-up and the patient will be submitted to IOL explant.Conclusion: Phakic IOLs were effective for correction high ametropia after DALK, showing high efficacy and safety indexes with stability over time. However, it was registered a continuing endothelial cell loss postoperatively, which assumed to be higher than those reported in eyes without DALK.Keywords: phakic intraocular lens, deep anterior lamellar keratoplasty, endothelial cell density, visual outcomes, refractive outcomes
format	article
author	Malheiro L Coelho J Neves MM Gomes M Oliveira L
author_facet	Malheiro L Coelho J Neves MM Gomes M Oliveira L
author_sort	Malheiro L
title	Phakic Intraocular Lens Implantation After Deep Anterior Lamellar Keratoplasty: Retrospective Case Series Analysis With Long-Term Follow-Up
title_short	Phakic Intraocular Lens Implantation After Deep Anterior Lamellar Keratoplasty: Retrospective Case Series Analysis With Long-Term Follow-Up
title_full	Phakic Intraocular Lens Implantation After Deep Anterior Lamellar Keratoplasty: Retrospective Case Series Analysis With Long-Term Follow-Up
title_fullStr	Phakic Intraocular Lens Implantation After Deep Anterior Lamellar Keratoplasty: Retrospective Case Series Analysis With Long-Term Follow-Up
title_full_unstemmed	Phakic Intraocular Lens Implantation After Deep Anterior Lamellar Keratoplasty: Retrospective Case Series Analysis With Long-Term Follow-Up
title_sort	phakic intraocular lens implantation after deep anterior lamellar keratoplasty: retrospective case series analysis with long-term follow-up
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/1fb801602d624fe9aa5dfa95d918529f
work_keys_str_mv	AT malheirol phakicintraocularlensimplantationafterdeepanteriorlamellarkeratoplastyretrospectivecaseseriesanalysiswithlongtermfollowup AT coelhoj phakicintraocularlensimplantationafterdeepanteriorlamellarkeratoplastyretrospectivecaseseriesanalysiswithlongtermfollowup AT nevesmm phakicintraocularlensimplantationafterdeepanteriorlamellarkeratoplastyretrospectivecaseseriesanalysiswithlongtermfollowup AT gomesm phakicintraocularlensimplantationafterdeepanteriorlamellarkeratoplastyretrospectivecaseseriesanalysiswithlongtermfollowup AT oliveiral phakicintraocularlensimplantationafterdeepanteriorlamellarkeratoplastyretrospectivecaseseriesanalysiswithlongtermfollowup
_version_	1718397991699611648

Phakic Intraocular Lens Implantation After Deep Anterior Lamellar Keratoplasty: Retrospective Case Series Analysis With Long-Term Follow-Up

Ejemplares similares