Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force

Abstract Following several years enrolling disease-specific and otherwise healthy cohorts into the Coriell Personalized Medicine Collaborative, a prospective study aimed at evaluating the clinical utility of personal genomic information for common complex disease and pharmacogenomics, the Coriell Pe...

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Autores principales:	Susan K. Delaney, Ruth Brenner, Tara J. Schmidlen, Michael P. Dempsey, Kim E. London, Erynn S. Gordon, Mark Bellafante, Ashley Nasuti, Laura B. Scheinfeldt, Kaveri D. Rajula, Leo Jose, Joseph P. Jarvis, Norman P. Gerry, Michael F. Christman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/1fbcf28497574158bb0e60cdda521aa4
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spelling	oai:doaj.org-article:1fbcf28497574158bb0e60cdda521aa42021-12-02T15:10:32ZPrecision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force10.1038/s41525-016-0004-12056-7944https://doaj.org/article/1fbcf28497574158bb0e60cdda521aa42017-01-01T00:00:00Zhttps://doi.org/10.1038/s41525-016-0004-1https://doaj.org/toc/2056-7944Abstract Following several years enrolling disease-specific and otherwise healthy cohorts into the Coriell Personalized Medicine Collaborative, a prospective study aimed at evaluating the clinical utility of personal genomic information for common complex disease and pharmacogenomics, the Coriell Personalized Medicine Collaborative expanded to create a military cohort, specifically, the United States Air Force. Initial recruitment focused on Air Force Medical Service personnel and later expanded to include all Active Duty Air Force members and beneficiaries. Now in its 6th year, the study has produced a wide variety of insights, including optimal study design for military-sponsored genomic research, and discussion on genetic information sharing between and amongst Air Force study participants, civilian and military researchers, and the United States Department of Defense. Over the longer term, analyses will further contribute to the development of policies and processes relevant to clinical decision support and data sharing within the US military, and on-going work with the Air Force Medical Service sub-cohort will generate critical insights into how best to deploy useful genomic information in clinical care. Here we discuss challenges faced and critical success factors for military-civilian collaborations around genomic research.Susan K. DelaneyRuth BrennerTara J. SchmidlenMichael P. DempseyKim E. LondonErynn S. GordonMark BellafanteAshley NasutiLaura B. ScheinfeldtKaveri D. RajulaLeo JoseJoseph P. JarvisNorman P. GerryMichael F. ChristmanNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 2, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Susan K. Delaney Ruth Brenner Tara J. Schmidlen Michael P. Dempsey Kim E. London Erynn S. Gordon Mark Bellafante Ashley Nasuti Laura B. Scheinfeldt Kaveri D. Rajula Leo Jose Joseph P. Jarvis Norman P. Gerry Michael F. Christman Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force
description	Abstract Following several years enrolling disease-specific and otherwise healthy cohorts into the Coriell Personalized Medicine Collaborative, a prospective study aimed at evaluating the clinical utility of personal genomic information for common complex disease and pharmacogenomics, the Coriell Personalized Medicine Collaborative expanded to create a military cohort, specifically, the United States Air Force. Initial recruitment focused on Air Force Medical Service personnel and later expanded to include all Active Duty Air Force members and beneficiaries. Now in its 6th year, the study has produced a wide variety of insights, including optimal study design for military-sponsored genomic research, and discussion on genetic information sharing between and amongst Air Force study participants, civilian and military researchers, and the United States Department of Defense. Over the longer term, analyses will further contribute to the development of policies and processes relevant to clinical decision support and data sharing within the US military, and on-going work with the Air Force Medical Service sub-cohort will generate critical insights into how best to deploy useful genomic information in clinical care. Here we discuss challenges faced and critical success factors for military-civilian collaborations around genomic research.
format	article
author	Susan K. Delaney Ruth Brenner Tara J. Schmidlen Michael P. Dempsey Kim E. London Erynn S. Gordon Mark Bellafante Ashley Nasuti Laura B. Scheinfeldt Kaveri D. Rajula Leo Jose Joseph P. Jarvis Norman P. Gerry Michael F. Christman
author_facet	Susan K. Delaney Ruth Brenner Tara J. Schmidlen Michael P. Dempsey Kim E. London Erynn S. Gordon Mark Bellafante Ashley Nasuti Laura B. Scheinfeldt Kaveri D. Rajula Leo Jose Joseph P. Jarvis Norman P. Gerry Michael F. Christman
author_sort	Susan K. Delaney
title	Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force
title_short	Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force
title_full	Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force
title_fullStr	Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force
title_full_unstemmed	Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force
title_sort	precision military medicine: conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the united states air force
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1fbcf28497574158bb0e60cdda521aa4
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Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force

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