Electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite

In this study, a simple voltammetric method was reported for independent determination of propranolol (PROP) and atenolol (ATN) in pharmaceutical tablets using carbon paste electrode modified with natural Ilmenite (CPE-I). The analytical performance of the modified sensor was evaluated using the squ...

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Autores principales:	Broli Nevila, Vasjari Majlinda, Vallja Loreta, Duka Sonila, Shehu Alma, Cenolli Sadik
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	β blockers square wave voltammetry ilmenite nanomaterial cyclic voltammetry pharmaceutical tablets Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/1fbe717eca84482eae0a3e341ca688ef
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spelling	oai:doaj.org-article:1fbe717eca84482eae0a3e341ca688ef2021-12-05T14:10:44ZElectrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite2391-542010.1515/chem-2021-0071https://doaj.org/article/1fbe717eca84482eae0a3e341ca688ef2021-08-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0071https://doaj.org/toc/2391-5420In this study, a simple voltammetric method was reported for independent determination of propranolol (PROP) and atenolol (ATN) in pharmaceutical tablets using carbon paste electrode modified with natural Ilmenite (CPE-I). The analytical performance of the modified sensor was evaluated using the square wave voltammetry and cyclic voltammetry for determination of both β(beta) blockers in 0.1 mol L−1 of sulfuric acid solution (H2SO4). The signal obtained with modified carbon paste electrode in 0.1 mol L−1 of H2SO4 showed a good electrocatalytic activity toward the oxidations of PROP and ATN compared with the bare one. The enhanced oxidation peak current response can be attributed to the catalytic effect of the ilmenite nanomaterial incorporated into the carbon paste electrode. Under optimal condition, good linear calibration curves were obtained ranging from 0.20 to 8.9 mmol L−1 for PROP and 2.0 to 9.9 µmol L−1 for ATN, with detection limits of 80 and 0.31 µmol L−1, respectively. The CPE-I sensor had good repeatability and reproducibility (RSD ≤ 3.2%) and high sensitivity for the detection of both ATN and PROP. The proposed sensor was applied for detection of these drugs in pharmaceutical tablets. The obtained results indicate that the voltammetric CPE-I sensor could be an alternative method for the routine quality control of the β blockers in complex matrices.Broli NevilaVasjari MajlindaVallja LoretaDuka SonilaShehu AlmaCenolli SadikDe Gruyterarticleβ blockerssquare wave voltammetryilmenite nanomaterialcyclic voltammetrypharmaceutical tabletsChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 875-883 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	β blockers square wave voltammetry ilmenite nanomaterial cyclic voltammetry pharmaceutical tablets Chemistry QD1-999
spellingShingle	β blockers square wave voltammetry ilmenite nanomaterial cyclic voltammetry pharmaceutical tablets Chemistry QD1-999 Broli Nevila Vasjari Majlinda Vallja Loreta Duka Sonila Shehu Alma Cenolli Sadik Electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite
description	In this study, a simple voltammetric method was reported for independent determination of propranolol (PROP) and atenolol (ATN) in pharmaceutical tablets using carbon paste electrode modified with natural Ilmenite (CPE-I). The analytical performance of the modified sensor was evaluated using the square wave voltammetry and cyclic voltammetry for determination of both β(beta) blockers in 0.1 mol L−1 of sulfuric acid solution (H2SO4). The signal obtained with modified carbon paste electrode in 0.1 mol L−1 of H2SO4 showed a good electrocatalytic activity toward the oxidations of PROP and ATN compared with the bare one. The enhanced oxidation peak current response can be attributed to the catalytic effect of the ilmenite nanomaterial incorporated into the carbon paste electrode. Under optimal condition, good linear calibration curves were obtained ranging from 0.20 to 8.9 mmol L−1 for PROP and 2.0 to 9.9 µmol L−1 for ATN, with detection limits of 80 and 0.31 µmol L−1, respectively. The CPE-I sensor had good repeatability and reproducibility (RSD ≤ 3.2%) and high sensitivity for the detection of both ATN and PROP. The proposed sensor was applied for detection of these drugs in pharmaceutical tablets. The obtained results indicate that the voltammetric CPE-I sensor could be an alternative method for the routine quality control of the β blockers in complex matrices.
format	article
author	Broli Nevila Vasjari Majlinda Vallja Loreta Duka Sonila Shehu Alma Cenolli Sadik
author_facet	Broli Nevila Vasjari Majlinda Vallja Loreta Duka Sonila Shehu Alma Cenolli Sadik
author_sort	Broli Nevila
title	Electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite
title_short	Electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite
title_full	Electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite
title_fullStr	Electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite
title_full_unstemmed	Electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite
title_sort	electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/1fbe717eca84482eae0a3e341ca688ef
work_keys_str_mv	AT brolinevila electrochemicaldeterminationofatenololandpropranololusingacarbonpastesensormodifiedwithnaturalilmenite AT vasjarimajlinda electrochemicaldeterminationofatenololandpropranololusingacarbonpastesensormodifiedwithnaturalilmenite AT valljaloreta electrochemicaldeterminationofatenololandpropranololusingacarbonpastesensormodifiedwithnaturalilmenite AT dukasonila electrochemicaldeterminationofatenololandpropranololusingacarbonpastesensormodifiedwithnaturalilmenite AT shehualma electrochemicaldeterminationofatenololandpropranololusingacarbonpastesensormodifiedwithnaturalilmenite AT cenollisadik electrochemicaldeterminationofatenololandpropranololusingacarbonpastesensormodifiedwithnaturalilmenite
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Electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite

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