Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast

Congenital Zika syndrome (CZS) is characterized by a diverse group of congenital malformations induced by ZIKV infection during pregnancy. Type III interferons have been associated with placental immunity against ZIKV and restriction of vertical transmission in mice, and non-coding single-nucleotide...

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Autores principales:	Átila Duque Rossi, Fabio Rueda Faucz, Adriana Melo, Girlene Souza de Azevedo, Paula Pezzuto, Ohanna Cavalcanti de Lima Bezerra, Fernanda Saloum de Neves Manta, Tamiris Azamor, Bruno Luiz Fonseca Schamber-Reis, Amilcar Tanuri, Milton Ozório Moraes, Renato Santana Aguiar, Constantine A. Stratakis, Cynthia Chester Cardoso
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Zika type III interferon polymorphism congenital Zika syndrome genetic susceptibility Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1fbefc8d57cb4b1ca2c49d02652c14c5
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spelling	oai:doaj.org-article:1fbefc8d57cb4b1ca2c49d02652c14c52021-11-25T19:13:48ZAssociation between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast10.3390/v131122531999-4915https://doaj.org/article/1fbefc8d57cb4b1ca2c49d02652c14c52021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2253https://doaj.org/toc/1999-4915Congenital Zika syndrome (CZS) is characterized by a diverse group of congenital malformations induced by ZIKV infection during pregnancy. Type III interferons have been associated with placental immunity against ZIKV and restriction of vertical transmission in mice, and non-coding single-nucleotide polymorphisms (SNPs) on these genes are well known to influence susceptibility to other viral infections. However, their effect on ZIKV pathogenesis has not yet been explored. To investigate whether maternal non-coding SNPs at <i>IFNL</i> genes are associated with CZS, 52 women infected with ZIKV during pregnancy were enrolled in a case–control association study. A total of 28 women were classified as cases and 24 as controls based on the presence or absence of CZS in their infants, and seven Interferon-λ non-coding SNPs (rs12980275, rs8099917, rs4803217, rs4803219, rs8119886, rs368234815, rs12979860) were genotyped. The results of logistic regression analyses show an association between the G allele at rs8099917 and increased susceptibility to CZS under a log-additive model (<sub>adjusted</sub>OR = 2.80; <sub>95%</sub>CI = 1.14–6.91; <i>p</i> = 0.02), after adjustment for trimester of infection and genetic ancestry. These results provide evidence of an association between Interferon-λ SNPs and CZS, suggesting rs8099917 as a promising candidate for further studies on larger cohorts.Átila Duque RossiFabio Rueda FauczAdriana MeloGirlene Souza de AzevedoPaula PezzutoOhanna Cavalcanti de Lima BezerraFernanda Saloum de Neves MantaTamiris AzamorBruno Luiz Fonseca Schamber-ReisAmilcar TanuriMilton Ozório MoraesRenato Santana AguiarConstantine A. StratakisCynthia Chester CardosoMDPI AGarticleZikatype III interferonpolymorphismcongenital Zika syndromegenetic susceptibilityMicrobiologyQR1-502ENViruses, Vol 13, Iss 2253, p 2253 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Zika type III interferon polymorphism congenital Zika syndrome genetic susceptibility Microbiology QR1-502
spellingShingle	Zika type III interferon polymorphism congenital Zika syndrome genetic susceptibility Microbiology QR1-502 Átila Duque Rossi Fabio Rueda Faucz Adriana Melo Girlene Souza de Azevedo Paula Pezzuto Ohanna Cavalcanti de Lima Bezerra Fernanda Saloum de Neves Manta Tamiris Azamor Bruno Luiz Fonseca Schamber-Reis Amilcar Tanuri Milton Ozório Moraes Renato Santana Aguiar Constantine A. Stratakis Cynthia Chester Cardoso Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast
description	Congenital Zika syndrome (CZS) is characterized by a diverse group of congenital malformations induced by ZIKV infection during pregnancy. Type III interferons have been associated with placental immunity against ZIKV and restriction of vertical transmission in mice, and non-coding single-nucleotide polymorphisms (SNPs) on these genes are well known to influence susceptibility to other viral infections. However, their effect on ZIKV pathogenesis has not yet been explored. To investigate whether maternal non-coding SNPs at <i>IFNL</i> genes are associated with CZS, 52 women infected with ZIKV during pregnancy were enrolled in a case–control association study. A total of 28 women were classified as cases and 24 as controls based on the presence or absence of CZS in their infants, and seven Interferon-λ non-coding SNPs (rs12980275, rs8099917, rs4803217, rs4803219, rs8119886, rs368234815, rs12979860) were genotyped. The results of logistic regression analyses show an association between the G allele at rs8099917 and increased susceptibility to CZS under a log-additive model (<sub>adjusted</sub>OR = 2.80; <sub>95%</sub>CI = 1.14–6.91; <i>p</i> = 0.02), after adjustment for trimester of infection and genetic ancestry. These results provide evidence of an association between Interferon-λ SNPs and CZS, suggesting rs8099917 as a promising candidate for further studies on larger cohorts.
format	article
author	Átila Duque Rossi Fabio Rueda Faucz Adriana Melo Girlene Souza de Azevedo Paula Pezzuto Ohanna Cavalcanti de Lima Bezerra Fernanda Saloum de Neves Manta Tamiris Azamor Bruno Luiz Fonseca Schamber-Reis Amilcar Tanuri Milton Ozório Moraes Renato Santana Aguiar Constantine A. Stratakis Cynthia Chester Cardoso
author_facet	Átila Duque Rossi Fabio Rueda Faucz Adriana Melo Girlene Souza de Azevedo Paula Pezzuto Ohanna Cavalcanti de Lima Bezerra Fernanda Saloum de Neves Manta Tamiris Azamor Bruno Luiz Fonseca Schamber-Reis Amilcar Tanuri Milton Ozório Moraes Renato Santana Aguiar Constantine A. Stratakis Cynthia Chester Cardoso
author_sort	Átila Duque Rossi
title	Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast
title_short	Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast
title_full	Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast
title_fullStr	Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast
title_full_unstemmed	Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast
title_sort	association between maternal non-coding interferon-λ polymorphisms and congenital zika syndrome in a cohort from brazilian northeast
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1fbefc8d57cb4b1ca2c49d02652c14c5
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Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast

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