Synthetic surfactant- and cross-linker-free preparation of highly stable lipid-polymer hybrid nanoparticles as potential oral delivery vehicles

Abstract The toxicity associated with concentrated synthetic surfactants and the poor stability at gastrointestinal condition are two major constraints for practical applications of solid lipid nanoparticles (SLN) as oral delivery vehicles. In this study, a synthetic surfactant-free and cross-linker...

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Autores principales:	Taoran Wang, Jingyi Xue, Qiaobin Hu, Mingyong Zhou, Chao Chang, Yangchao Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1fbf6d14ecc64ba68350601cfba9d227
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spelling	oai:doaj.org-article:1fbf6d14ecc64ba68350601cfba9d2272021-12-02T15:05:35ZSynthetic surfactant- and cross-linker-free preparation of highly stable lipid-polymer hybrid nanoparticles as potential oral delivery vehicles10.1038/s41598-017-02867-x2045-2322https://doaj.org/article/1fbf6d14ecc64ba68350601cfba9d2272017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02867-xhttps://doaj.org/toc/2045-2322Abstract The toxicity associated with concentrated synthetic surfactants and the poor stability at gastrointestinal condition are two major constraints for practical applications of solid lipid nanoparticles (SLN) as oral delivery vehicles. In this study, a synthetic surfactant-free and cross-linker-free method was developed to fabricate effective, safe, and ultra-stable lipid-polymer hybrid nanoparticles (LPN). Bovine serum albumin (BSA) and dextran varying in molecular weights were first conjugated through Maillard reaction and the conjugates were exploited to emulsify solid lipid by a solvent diffusion and sonication method. The multilayer structure was formed by self-assembly of BSA-dextran micelles to envelope solid lipid via a pH- and heating-induced facile process with simultaneous surface deposition of pectin. The efficiency of different BSA-dextran conjugates was systematically studied to prepare LPN with the smallest size, the most homogeneous distribution and the greatest stability. The molecular interactions were characterized by Fourier transform infrared and fluorescence spectroscopies. Both nano spray drying and freeze-drying methods were tested to produce spherical and uniform pectin-coated LPN powders that were able to re-assemble nanoscale structure when redispersed in water. The results demonstrated the promise of a synthetic surfactant- and cross-linker-free technique to prepare highly stable pectin-coated LPN from all natural biomaterials as potential oral delivery vehicles.Taoran WangJingyi XueQiaobin HuMingyong ZhouChao ChangYangchao LuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Taoran Wang Jingyi Xue Qiaobin Hu Mingyong Zhou Chao Chang Yangchao Luo Synthetic surfactant- and cross-linker-free preparation of highly stable lipid-polymer hybrid nanoparticles as potential oral delivery vehicles
description	Abstract The toxicity associated with concentrated synthetic surfactants and the poor stability at gastrointestinal condition are two major constraints for practical applications of solid lipid nanoparticles (SLN) as oral delivery vehicles. In this study, a synthetic surfactant-free and cross-linker-free method was developed to fabricate effective, safe, and ultra-stable lipid-polymer hybrid nanoparticles (LPN). Bovine serum albumin (BSA) and dextran varying in molecular weights were first conjugated through Maillard reaction and the conjugates were exploited to emulsify solid lipid by a solvent diffusion and sonication method. The multilayer structure was formed by self-assembly of BSA-dextran micelles to envelope solid lipid via a pH- and heating-induced facile process with simultaneous surface deposition of pectin. The efficiency of different BSA-dextran conjugates was systematically studied to prepare LPN with the smallest size, the most homogeneous distribution and the greatest stability. The molecular interactions were characterized by Fourier transform infrared and fluorescence spectroscopies. Both nano spray drying and freeze-drying methods were tested to produce spherical and uniform pectin-coated LPN powders that were able to re-assemble nanoscale structure when redispersed in water. The results demonstrated the promise of a synthetic surfactant- and cross-linker-free technique to prepare highly stable pectin-coated LPN from all natural biomaterials as potential oral delivery vehicles.
format	article
author	Taoran Wang Jingyi Xue Qiaobin Hu Mingyong Zhou Chao Chang Yangchao Luo
author_facet	Taoran Wang Jingyi Xue Qiaobin Hu Mingyong Zhou Chao Chang Yangchao Luo
author_sort	Taoran Wang
title	Synthetic surfactant- and cross-linker-free preparation of highly stable lipid-polymer hybrid nanoparticles as potential oral delivery vehicles
title_short	Synthetic surfactant- and cross-linker-free preparation of highly stable lipid-polymer hybrid nanoparticles as potential oral delivery vehicles
title_full	Synthetic surfactant- and cross-linker-free preparation of highly stable lipid-polymer hybrid nanoparticles as potential oral delivery vehicles
title_fullStr	Synthetic surfactant- and cross-linker-free preparation of highly stable lipid-polymer hybrid nanoparticles as potential oral delivery vehicles
title_full_unstemmed	Synthetic surfactant- and cross-linker-free preparation of highly stable lipid-polymer hybrid nanoparticles as potential oral delivery vehicles
title_sort	synthetic surfactant- and cross-linker-free preparation of highly stable lipid-polymer hybrid nanoparticles as potential oral delivery vehicles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1fbf6d14ecc64ba68350601cfba9d227
work_keys_str_mv	AT taoranwang syntheticsurfactantandcrosslinkerfreepreparationofhighlystablelipidpolymerhybridnanoparticlesaspotentialoraldeliveryvehicles AT jingyixue syntheticsurfactantandcrosslinkerfreepreparationofhighlystablelipidpolymerhybridnanoparticlesaspotentialoraldeliveryvehicles AT qiaobinhu syntheticsurfactantandcrosslinkerfreepreparationofhighlystablelipidpolymerhybridnanoparticlesaspotentialoraldeliveryvehicles AT mingyongzhou syntheticsurfactantandcrosslinkerfreepreparationofhighlystablelipidpolymerhybridnanoparticlesaspotentialoraldeliveryvehicles AT chaochang syntheticsurfactantandcrosslinkerfreepreparationofhighlystablelipidpolymerhybridnanoparticlesaspotentialoraldeliveryvehicles AT yangchaoluo syntheticsurfactantandcrosslinkerfreepreparationofhighlystablelipidpolymerhybridnanoparticlesaspotentialoraldeliveryvehicles
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Synthetic surfactant- and cross-linker-free preparation of highly stable lipid-polymer hybrid nanoparticles as potential oral delivery vehicles

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