C. elegans germ granules require both assembly and localized regulators for mRNA repression

Nematode P granules are cytoplasmic RNA–protein biomolecule condensates central to germ cell development. Here the authors show that dimerization of the PGL-1 scaffolding protein is crucial to granule formation and mRNA repression, and that the WAGO-1 Argonaute protein is a cofactor in repressing PG...

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Autores principales:	Scott Takeo Aoki, Tina R. Lynch, Sarah L. Crittenden, Craig A. Bingman, Marvin Wickens, Judith Kimble
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fc26fa5125a4471a584495d77e492d1
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spelling	oai:doaj.org-article:1fc26fa5125a4471a584495d77e492d12021-12-02T14:10:56ZC. elegans germ granules require both assembly and localized regulators for mRNA repression10.1038/s41467-021-21278-12041-1723https://doaj.org/article/1fc26fa5125a4471a584495d77e492d12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21278-1https://doaj.org/toc/2041-1723Nematode P granules are cytoplasmic RNA–protein biomolecule condensates central to germ cell development. Here the authors show that dimerization of the PGL-1 scaffolding protein is crucial to granule formation and mRNA repression, and that the WAGO-1 Argonaute protein is a cofactor in repressing PGL-1 bound mRNAs.Scott Takeo AokiTina R. LynchSarah L. CrittendenCraig A. BingmanMarvin WickensJudith KimbleNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Scott Takeo Aoki Tina R. Lynch Sarah L. Crittenden Craig A. Bingman Marvin Wickens Judith Kimble C. elegans germ granules require both assembly and localized regulators for mRNA repression
description	Nematode P granules are cytoplasmic RNA–protein biomolecule condensates central to germ cell development. Here the authors show that dimerization of the PGL-1 scaffolding protein is crucial to granule formation and mRNA repression, and that the WAGO-1 Argonaute protein is a cofactor in repressing PGL-1 bound mRNAs.
format	article
author	Scott Takeo Aoki Tina R. Lynch Sarah L. Crittenden Craig A. Bingman Marvin Wickens Judith Kimble
author_facet	Scott Takeo Aoki Tina R. Lynch Sarah L. Crittenden Craig A. Bingman Marvin Wickens Judith Kimble
author_sort	Scott Takeo Aoki
title	C. elegans germ granules require both assembly and localized regulators for mRNA repression
title_short	C. elegans germ granules require both assembly and localized regulators for mRNA repression
title_full	C. elegans germ granules require both assembly and localized regulators for mRNA repression
title_fullStr	C. elegans germ granules require both assembly and localized regulators for mRNA repression
title_full_unstemmed	C. elegans germ granules require both assembly and localized regulators for mRNA repression
title_sort	c. elegans germ granules require both assembly and localized regulators for mrna repression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1fc26fa5125a4471a584495d77e492d1
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C. elegans germ granules require both assembly and localized regulators for mRNA repression

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