C. elegans germ granules require both assembly and localized regulators for mRNA repression

C. elegans germ granules require both assembly and localized regulators for mRNA repression

Nematode P granules are cytoplasmic RNA–protein biomolecule condensates central to germ cell development. Here the authors show that dimerization of the PGL-1 scaffolding protein is crucial to granule formation and mRNA repression, and that the WAGO-1 Argonaute protein is a cofactor in repressing PG...

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Autores principales: Scott Takeo Aoki, Tina R. Lynch, Sarah L. Crittenden, Craig A. Bingman, Marvin Wickens, Judith Kimble
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/1fc26fa5125a4471a584495d77e492d1
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