Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury

Severe malaria can be associated with respiratory complications. Here, the authors show that malaria-associated pulmonary vascular damage is a consequence of IFNγ-activated lung endothelial cells capturing, processing, and cross-presenting malaria parasite antigen to specific CD8+ T cells induced du...

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Autores principales:	Carla Claser, Samantha Yee Teng Nguee, Akhila Balachander, Shanshan Wu Howland, Etienne Becht, Bavani Gunasegaran, Siddesh V. Hartimath, Audrey W. Q. Lee, Jacqueline Theng Theng Ho, Chee Bing Ong, Evan W. Newell, Julian Goggi, Lai Guan Ng, Laurent Renia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fc2aedd388244a98e0a91adeebd988e
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spelling	oai:doaj.org-article:1fc2aedd388244a98e0a91adeebd988e2021-12-02T15:35:40ZLung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury10.1038/s41467-019-12017-82041-1723https://doaj.org/article/1fc2aedd388244a98e0a91adeebd988e2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12017-8https://doaj.org/toc/2041-1723Severe malaria can be associated with respiratory complications. Here, the authors show that malaria-associated pulmonary vascular damage is a consequence of IFNγ-activated lung endothelial cells capturing, processing, and cross-presenting malaria parasite antigen to specific CD8+ T cells induced during infection.Carla ClaserSamantha Yee Teng NgueeAkhila BalachanderShanshan Wu HowlandEtienne BechtBavani GunasegaranSiddesh V. HartimathAudrey W. Q. LeeJacqueline Theng Theng HoChee Bing OngEvan W. NewellJulian GoggiLai Guan NgLaurent ReniaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carla Claser Samantha Yee Teng Nguee Akhila Balachander Shanshan Wu Howland Etienne Becht Bavani Gunasegaran Siddesh V. Hartimath Audrey W. Q. Lee Jacqueline Theng Theng Ho Chee Bing Ong Evan W. Newell Julian Goggi Lai Guan Ng Laurent Renia Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury
description	Severe malaria can be associated with respiratory complications. Here, the authors show that malaria-associated pulmonary vascular damage is a consequence of IFNγ-activated lung endothelial cells capturing, processing, and cross-presenting malaria parasite antigen to specific CD8+ T cells induced during infection.
format	article
author	Carla Claser Samantha Yee Teng Nguee Akhila Balachander Shanshan Wu Howland Etienne Becht Bavani Gunasegaran Siddesh V. Hartimath Audrey W. Q. Lee Jacqueline Theng Theng Ho Chee Bing Ong Evan W. Newell Julian Goggi Lai Guan Ng Laurent Renia
author_facet	Carla Claser Samantha Yee Teng Nguee Akhila Balachander Shanshan Wu Howland Etienne Becht Bavani Gunasegaran Siddesh V. Hartimath Audrey W. Q. Lee Jacqueline Theng Theng Ho Chee Bing Ong Evan W. Newell Julian Goggi Lai Guan Ng Laurent Renia
author_sort	Carla Claser
title	Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury
title_short	Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury
title_full	Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury
title_fullStr	Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury
title_full_unstemmed	Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury
title_sort	lung endothelial cell antigen cross-presentation to cd8+t cells drives malaria-associated lung injury
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1fc2aedd388244a98e0a91adeebd988e
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Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury

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