THERAPEUTIC PLASMA EXCHANGE IN PATIENTS WITH NEUROLOGICAL DISEASES: A 9-YEAR, SINGLE-CENTER EXPERIENCE

Objective: Therapeutic plasma exchange (TPE), is based on the removal of pathogenic substrates from plasma with replacement fluid. TPE is being used in the treatment of many neurological diseases, especially Myasthenia Gravis (MG) and Guillain Barre Syndrome (GBS). The aim of this study is to analy...

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Autores principales:	Merih Reis Aras, Murat Albayrak, Hacer Berna Afacan Ozturk, Fatma Yilmaz, Bugra Saglam, Mehlika Panpalli Ates, Selim Selcuk Comoglu, Abdulkerim Yildiz
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/1fc5558b8ebd4fc58cc9cce55e3b74aa
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spelling	oai:doaj.org-article:1fc5558b8ebd4fc58cc9cce55e3b74aa2021-11-10T04:37:21ZTHERAPEUTIC PLASMA EXCHANGE IN PATIENTS WITH NEUROLOGICAL DISEASES: A 9-YEAR, SINGLE-CENTER EXPERIENCE2531-137910.1016/j.htct.2021.10.1055https://doaj.org/article/1fc5558b8ebd4fc58cc9cce55e3b74aa2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921012025https://doaj.org/toc/2531-1379Objective: Therapeutic plasma exchange (TPE), is based on the removal of pathogenic substrates from plasma with replacement fluid. TPE is being used in the treatment of many neurological diseases, especially Myasthenia Gravis (MG) and Guillain Barre Syndrome (GBS). The aim of this study is to analyse the efficay and safety of TPE experience in neurological disorders. Methodology: We reviewed the medical records of all 59 patients who received a total of 267 therapeutic cycles between 2012 and 2021 in our tertiary care university hospital. Respond assesment was evaluated with Medical Research Council (MRC) scoring system. Neutrophil count, lymphocyte count and neutrophil/lymphocyte ratio was recorded before any treatment and 7 days after the last plasmapheresis cycle. Results: Of the 59 patients, 30 (50.8%) were male and 29 (49.2%) were female. Of these patients 44.1% were diagnosed with MG, 27.3% with GBS, %8.5 with Multiple Sclerosis (MS). The median number of TPE sessions per patient was 5 [1-7]. 33.9 % of patients had at least one complication that hypotension was the most seen (%22). Overall response rate was %76.3. MRC score was significantly higher in the group with response than the group without symptom regression (p <0.05). Conclusion: TPE is a safe and an effective treatment option in neurological diseases. TPE related side effects/complications were generally mild to moderate and manageable. Performing the TPE response evaluation with the MRC scoring system was beneficial for the reliability of the efficacy as a concrete finding.Merih Reis ArasMurat AlbayrakHacer Berna Afacan OzturkFatma YilmazBugra SaglamMehlika Panpalli AtesSelim Selcuk ComogluAbdulkerim YildizElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S49- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Merih Reis Aras Murat Albayrak Hacer Berna Afacan Ozturk Fatma Yilmaz Bugra Saglam Mehlika Panpalli Ates Selim Selcuk Comoglu Abdulkerim Yildiz THERAPEUTIC PLASMA EXCHANGE IN PATIENTS WITH NEUROLOGICAL DISEASES: A 9-YEAR, SINGLE-CENTER EXPERIENCE
description	Objective: Therapeutic plasma exchange (TPE), is based on the removal of pathogenic substrates from plasma with replacement fluid. TPE is being used in the treatment of many neurological diseases, especially Myasthenia Gravis (MG) and Guillain Barre Syndrome (GBS). The aim of this study is to analyse the efficay and safety of TPE experience in neurological disorders. Methodology: We reviewed the medical records of all 59 patients who received a total of 267 therapeutic cycles between 2012 and 2021 in our tertiary care university hospital. Respond assesment was evaluated with Medical Research Council (MRC) scoring system. Neutrophil count, lymphocyte count and neutrophil/lymphocyte ratio was recorded before any treatment and 7 days after the last plasmapheresis cycle. Results: Of the 59 patients, 30 (50.8%) were male and 29 (49.2%) were female. Of these patients 44.1% were diagnosed with MG, 27.3% with GBS, %8.5 with Multiple Sclerosis (MS). The median number of TPE sessions per patient was 5 [1-7]. 33.9 % of patients had at least one complication that hypotension was the most seen (%22). Overall response rate was %76.3. MRC score was significantly higher in the group with response than the group without symptom regression (p <0.05). Conclusion: TPE is a safe and an effective treatment option in neurological diseases. TPE related side effects/complications were generally mild to moderate and manageable. Performing the TPE response evaluation with the MRC scoring system was beneficial for the reliability of the efficacy as a concrete finding.
format	article
author	Merih Reis Aras Murat Albayrak Hacer Berna Afacan Ozturk Fatma Yilmaz Bugra Saglam Mehlika Panpalli Ates Selim Selcuk Comoglu Abdulkerim Yildiz
author_facet	Merih Reis Aras Murat Albayrak Hacer Berna Afacan Ozturk Fatma Yilmaz Bugra Saglam Mehlika Panpalli Ates Selim Selcuk Comoglu Abdulkerim Yildiz
author_sort	Merih Reis Aras
title	THERAPEUTIC PLASMA EXCHANGE IN PATIENTS WITH NEUROLOGICAL DISEASES: A 9-YEAR, SINGLE-CENTER EXPERIENCE
title_short	THERAPEUTIC PLASMA EXCHANGE IN PATIENTS WITH NEUROLOGICAL DISEASES: A 9-YEAR, SINGLE-CENTER EXPERIENCE
title_full	THERAPEUTIC PLASMA EXCHANGE IN PATIENTS WITH NEUROLOGICAL DISEASES: A 9-YEAR, SINGLE-CENTER EXPERIENCE
title_fullStr	THERAPEUTIC PLASMA EXCHANGE IN PATIENTS WITH NEUROLOGICAL DISEASES: A 9-YEAR, SINGLE-CENTER EXPERIENCE
title_full_unstemmed	THERAPEUTIC PLASMA EXCHANGE IN PATIENTS WITH NEUROLOGICAL DISEASES: A 9-YEAR, SINGLE-CENTER EXPERIENCE
title_sort	therapeutic plasma exchange in patients with neurological diseases: a 9-year, single-center experience
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1fc5558b8ebd4fc58cc9cce55e3b74aa
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THERAPEUTIC PLASMA EXCHANGE IN PATIENTS WITH NEUROLOGICAL DISEASES: A 9-YEAR, SINGLE-CENTER EXPERIENCE

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