Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography

Yasuyuki Yamauchi, Hiromichi Yagi, Yoshihiko Usui, Keisuke Kimura, Tsuyoshi Agawa, Rintaro Tsukahara, Naoyuki Yamakawa, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanBackground: Recent research on macular diseases has prompted investigations into the conditi...

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Autores principales:	Yamauchi Y, Yagi H, Usui Y, Kimura K, Agawa T, Tsukahara R, Yamakawa N, Goto H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1fc7c2933af44246ae9151702e69f506
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spelling	oai:doaj.org-article:1fc7c2933af44246ae9151702e69f5062021-12-02T07:18:29ZBiological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography1177-54671177-5483https://doaj.org/article/1fc7c2933af44246ae9151702e69f5062011-11-01T00:00:00Zhttp://www.dovepress.com/biological-activity-is-the-likely-origin-of-the-intersection-between-t-a8706https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Yasuyuki Yamauchi, Hiromichi Yagi, Yoshihiko Usui, Keisuke Kimura, Tsuyoshi Agawa, Rintaro Tsukahara, Naoyuki Yamakawa, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanBackground: Recent research on macular diseases has prompted investigations into the condition of the intersection between the photoreceptor inner and outer segments (IS/OS) and the relationship with retinal photoreceptor abnormalities. Although the origin of the IS/OS in optical coherence tomography (OCT) images is unclear, it may be related to either the cellular activity of the photoreceptors or the structure of the OS disks. To address this question, we compared the IS/OS status in OCT images of rat retinas before and after euthanasia.Methods: OCT images were taken before and after euthanasia in four eyes of two Brown Norway rats. After the OCT images were taken, the rats were used for histopathological studies to confirm that retinal structures were intact.Results: Before euthanasia, the IS/OS and external limiting membrane (ELM) line were clearly identifiable on the OCT images. However, after euthanasia, neither the IS/OS nor the ELM line was evident in three out of four eyes, and a faint IS/OS and an ELM line were identified in one eye. Histopathological analysis did not show any abnormalities in the retina in any of the four eyes.Conclusion: The origin of the IS/OS identified in OCT images is likely related to the biological activities of the photoreceptor cells.Keywords: IS/OS, OCT, histopathology, biological activityYamauchi YYagi HUsui YKimura KAgawa TTsukahara RYamakawa NGoto HDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1649-1653 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Yamauchi Y Yagi H Usui Y Kimura K Agawa T Tsukahara R Yamakawa N Goto H Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography
description	Yasuyuki Yamauchi, Hiromichi Yagi, Yoshihiko Usui, Keisuke Kimura, Tsuyoshi Agawa, Rintaro Tsukahara, Naoyuki Yamakawa, Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, JapanBackground: Recent research on macular diseases has prompted investigations into the condition of the intersection between the photoreceptor inner and outer segments (IS/OS) and the relationship with retinal photoreceptor abnormalities. Although the origin of the IS/OS in optical coherence tomography (OCT) images is unclear, it may be related to either the cellular activity of the photoreceptors or the structure of the OS disks. To address this question, we compared the IS/OS status in OCT images of rat retinas before and after euthanasia.Methods: OCT images were taken before and after euthanasia in four eyes of two Brown Norway rats. After the OCT images were taken, the rats were used for histopathological studies to confirm that retinal structures were intact.Results: Before euthanasia, the IS/OS and external limiting membrane (ELM) line were clearly identifiable on the OCT images. However, after euthanasia, neither the IS/OS nor the ELM line was evident in three out of four eyes, and a faint IS/OS and an ELM line were identified in one eye. Histopathological analysis did not show any abnormalities in the retina in any of the four eyes.Conclusion: The origin of the IS/OS identified in OCT images is likely related to the biological activities of the photoreceptor cells.Keywords: IS/OS, OCT, histopathology, biological activity
format	article
author	Yamauchi Y Yagi H Usui Y Kimura K Agawa T Tsukahara R Yamakawa N Goto H
author_facet	Yamauchi Y Yagi H Usui Y Kimura K Agawa T Tsukahara R Yamakawa N Goto H
author_sort	Yamauchi Y
title	Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography
title_short	Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography
title_full	Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography
title_fullStr	Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography
title_full_unstemmed	Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography
title_sort	biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/1fc7c2933af44246ae9151702e69f506
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Biological activity is the likely origin of the intersection between the photoreceptor inner and outer segments of the rat retina as determined by optical coherence tomography

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