Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. Obj...

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Autores principales:	Jin Wang, Lin Wang, Guan-Hua Lou, Hai-Rong Zeng, Ju Hu, Qin-Wan Huang, Wei Peng, Xiang-Bo Yang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	huanglian morphology alkaloids berberine pharmacokinetics toxicity Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/1fc89fce1cae4ea1b295992c0aca0bea
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spelling	oai:doaj.org-article:1fc89fce1cae4ea1b295992c0aca0bea2021-11-17T14:21:55ZCoptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology1388-02091744-511610.1080/13880209.2019.1577466https://doaj.org/article/1fc89fce1cae4ea1b295992c0aca0bea2019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1577466https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. Objectives: The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives. Methods: Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread. Results: Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR. Conclusions: As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.Jin WangLin WangGuan-Hua LouHai-Rong ZengJu HuQin-Wan HuangWei PengXiang-Bo YangTaylor & Francis GrouparticlehuanglianmorphologyalkaloidsberberinepharmacokineticstoxicityTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 193-225 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	huanglian morphology alkaloids berberine pharmacokinetics toxicity Therapeutics. Pharmacology RM1-950
spellingShingle	huanglian morphology alkaloids berberine pharmacokinetics toxicity Therapeutics. Pharmacology RM1-950 Jin Wang Lin Wang Guan-Hua Lou Hai-Rong Zeng Ju Hu Qin-Wan Huang Wei Peng Xiang-Bo Yang Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
description	Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. Objectives: The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives. Methods: Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread. Results: Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR. Conclusions: As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.
format	article
author	Jin Wang Lin Wang Guan-Hua Lou Hai-Rong Zeng Ju Hu Qin-Wan Huang Wei Peng Xiang-Bo Yang
author_facet	Jin Wang Lin Wang Guan-Hua Lou Hai-Rong Zeng Ju Hu Qin-Wan Huang Wei Peng Xiang-Bo Yang
author_sort	Jin Wang
title	Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
title_short	Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
title_full	Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
title_fullStr	Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
title_full_unstemmed	Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
title_sort	coptidis rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/1fc89fce1cae4ea1b295992c0aca0bea
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Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

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