The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration

Tissue-engineered nerve grafts (TENGs) are the most promising way for repairing long-distance peripheral nerve defects. Chitosan and poly (lactic-co-glycolic acid) (PLGA) scaffolds are considered as the promising materials in the pharmaceutical and biomedical fields especially in the field of tissue...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Panjian Lu, Gang Wang, Tianmei Qian, Xiaodong Cai, Ping Zhang, Meiyuan Li, Yinying Shen, Chengbin Xue, Hongkui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	PLGA Schwann cells Regeneration microenvironment Inflammation Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1fc9be8a71e44b218d7bdc3d9f62c480
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1fc9be8a71e44b218d7bdc3d9f62c480
record_format	dspace
spelling	oai:doaj.org-article:1fc9be8a71e44b218d7bdc3d9f62c4802021-11-18T04:51:18ZThe balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration2590-006410.1016/j.mtbio.2021.100158https://doaj.org/article/1fc9be8a71e44b218d7bdc3d9f62c4802021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590006421000661https://doaj.org/toc/2590-0064Tissue-engineered nerve grafts (TENGs) are the most promising way for repairing long-distance peripheral nerve defects. Chitosan and poly (lactic-co-glycolic acid) (PLGA) scaffolds are considered as the promising materials in the pharmaceutical and biomedical fields especially in the field of tissue engineering. To further clarify the effects of a chitosan conduit inserted with various quantity of poly (lactic-co-glycolic acid) (PLGA) scaffolds, and their degrades on the peripheral nerve regeneration, the chitosan nerve conduit inserted with different amounts of PLGA scaffolds were used to repair rat sciatic nerve defects. The peripheral nerve regeneration at the different time points was dynamically and comprehensively evaluated. Moreover, the influence of different amounts of PLGA scaffolds on the regeneration microenvironment including inflammatory response and cell state were also revealed. The modest abundance of PLGA is more instrumental to the success of nerve regeneration, which is demonstrated in terms of the structure of the regenerated nerve, reinnervation of the target muscle, nerve impulse conduction, and overall function. The PLGA scaffolds aid the migration and maturation of Schwann cells. Furthermore, the PLGA and chitosan degradation products in a correct ratio neutralize, reducing the inflammatory response and enhancing the regeneration microenvironment. The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration. The findings represent a further step towards programming TENGs construction, applying polyester materials in regenerative medicine, and understanding the neural regeneration microenvironment.Panjian LuGang WangTianmei QianXiaodong CaiPing ZhangMeiyuan LiYinying ShenChengbin XueHongkui WangElsevierarticlePLGASchwann cellsRegeneration microenvironmentInflammationMedicine (General)R5-920Biology (General)QH301-705.5ENMaterials Today Bio, Vol 12, Iss , Pp 100158- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PLGA Schwann cells Regeneration microenvironment Inflammation Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	PLGA Schwann cells Regeneration microenvironment Inflammation Medicine (General) R5-920 Biology (General) QH301-705.5 Panjian Lu Gang Wang Tianmei Qian Xiaodong Cai Ping Zhang Meiyuan Li Yinying Shen Chengbin Xue Hongkui Wang The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration
description	Tissue-engineered nerve grafts (TENGs) are the most promising way for repairing long-distance peripheral nerve defects. Chitosan and poly (lactic-co-glycolic acid) (PLGA) scaffolds are considered as the promising materials in the pharmaceutical and biomedical fields especially in the field of tissue engineering. To further clarify the effects of a chitosan conduit inserted with various quantity of poly (lactic-co-glycolic acid) (PLGA) scaffolds, and their degrades on the peripheral nerve regeneration, the chitosan nerve conduit inserted with different amounts of PLGA scaffolds were used to repair rat sciatic nerve defects. The peripheral nerve regeneration at the different time points was dynamically and comprehensively evaluated. Moreover, the influence of different amounts of PLGA scaffolds on the regeneration microenvironment including inflammatory response and cell state were also revealed. The modest abundance of PLGA is more instrumental to the success of nerve regeneration, which is demonstrated in terms of the structure of the regenerated nerve, reinnervation of the target muscle, nerve impulse conduction, and overall function. The PLGA scaffolds aid the migration and maturation of Schwann cells. Furthermore, the PLGA and chitosan degradation products in a correct ratio neutralize, reducing the inflammatory response and enhancing the regeneration microenvironment. The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration. The findings represent a further step towards programming TENGs construction, applying polyester materials in regenerative medicine, and understanding the neural regeneration microenvironment.
format	article
author	Panjian Lu Gang Wang Tianmei Qian Xiaodong Cai Ping Zhang Meiyuan Li Yinying Shen Chengbin Xue Hongkui Wang
author_facet	Panjian Lu Gang Wang Tianmei Qian Xiaodong Cai Ping Zhang Meiyuan Li Yinying Shen Chengbin Xue Hongkui Wang
author_sort	Panjian Lu
title	The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration
title_short	The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration
title_full	The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration
title_fullStr	The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration
title_full_unstemmed	The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration
title_sort	balanced microenvironment regulated by the degradants of appropriate plga scaffolds and chitosan conduit promotes peripheral nerve regeneration
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1fc9be8a71e44b218d7bdc3d9f62c480
work_keys_str_mv	AT panjianlu thebalancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT gangwang thebalancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT tianmeiqian thebalancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT xiaodongcai thebalancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT pingzhang thebalancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT meiyuanli thebalancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT yinyingshen thebalancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT chengbinxue thebalancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT hongkuiwang thebalancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT panjianlu balancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT gangwang balancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT tianmeiqian balancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT xiaodongcai balancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT pingzhang balancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT meiyuanli balancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT yinyingshen balancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT chengbinxue balancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration AT hongkuiwang balancedmicroenvironmentregulatedbythedegradantsofappropriateplgascaffoldsandchitosanconduitpromotesperipheralnerveregeneration
_version_	1718424961370030080

The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration

Ejemplares similares