Comparative Y-chromosome analysis among Cypriots in the context of historical events and migrations.

Y-chromosome analysis provides valuable information regarding the migration patterns of male ancestors, ranging from the Paleolithic age to the modern humans. STR and SNP genotyping analysis provides data regarding the genetic and geographical ancestry of the populations studied. This study focused...

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Autores principales:	Irene Moutsouri, Anna Keravnou, Panayiotis Manoli, Stefania Bertoncini, Kyriaki Michailidou, Vasilis Christofi, Stavroulla Xenophontos, Marios A Cariolou, Evy Bashiardes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1fca0ea311214be4ab7405ecb8e05253
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spelling	oai:doaj.org-article:1fca0ea311214be4ab7405ecb8e052532021-12-02T20:14:56ZComparative Y-chromosome analysis among Cypriots in the context of historical events and migrations.1932-620310.1371/journal.pone.0255140https://doaj.org/article/1fca0ea311214be4ab7405ecb8e052532021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255140https://doaj.org/toc/1932-6203Y-chromosome analysis provides valuable information regarding the migration patterns of male ancestors, ranging from the Paleolithic age to the modern humans. STR and SNP genotyping analysis provides data regarding the genetic and geographical ancestry of the populations studied. This study focused on the analysis of the Y-chromosome in Maronite Cypriots and Armenian Cypriots, who came to the island as a result of different historical events. The aim was to provide information on the paternal genetic ancestry of Maronites and Armenians of Cyprus and investigate any affinity with the Greek Cypriots and Turkish Cypriots of the island. Since there is limited information in the current literature, we proceeded and used 23 Y-chromosome STRs and 28 Y-chromosome SNPs to genotype 57 Maronite Cypriots and 56 Armenian Cypriots, which were then compared to data from 344 Greek Cypriots and 380 Turkish Cypriots. All samples were assigned to eight major Y-haplogroups but the most frequent haplogroup among all Cypriots is haplogroup J in the major subclade J2a-L559. The calculated pairwise genetic distances between the populations show that Armenian Cypriots are genetically closer to Greek and Turkish Cypriots compared to Maronite Cypriots. Median Joining Network analysis in 17 Y-STR haplotypes of all Cypriots assigned to J2a-L559, revealed that Cypriots share a common paternal ancestor, prior to the migration of the Armenians and Maronites to Cyprus, estimated in the Late Bronze Age and Early Iron Age.Irene MoutsouriAnna KeravnouPanayiotis ManoliStefania BertonciniKyriaki MichailidouVasilis ChristofiStavroulla XenophontosMarios A CariolouEvy BashiardesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255140 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Irene Moutsouri Anna Keravnou Panayiotis Manoli Stefania Bertoncini Kyriaki Michailidou Vasilis Christofi Stavroulla Xenophontos Marios A Cariolou Evy Bashiardes Comparative Y-chromosome analysis among Cypriots in the context of historical events and migrations.
description	Y-chromosome analysis provides valuable information regarding the migration patterns of male ancestors, ranging from the Paleolithic age to the modern humans. STR and SNP genotyping analysis provides data regarding the genetic and geographical ancestry of the populations studied. This study focused on the analysis of the Y-chromosome in Maronite Cypriots and Armenian Cypriots, who came to the island as a result of different historical events. The aim was to provide information on the paternal genetic ancestry of Maronites and Armenians of Cyprus and investigate any affinity with the Greek Cypriots and Turkish Cypriots of the island. Since there is limited information in the current literature, we proceeded and used 23 Y-chromosome STRs and 28 Y-chromosome SNPs to genotype 57 Maronite Cypriots and 56 Armenian Cypriots, which were then compared to data from 344 Greek Cypriots and 380 Turkish Cypriots. All samples were assigned to eight major Y-haplogroups but the most frequent haplogroup among all Cypriots is haplogroup J in the major subclade J2a-L559. The calculated pairwise genetic distances between the populations show that Armenian Cypriots are genetically closer to Greek and Turkish Cypriots compared to Maronite Cypriots. Median Joining Network analysis in 17 Y-STR haplotypes of all Cypriots assigned to J2a-L559, revealed that Cypriots share a common paternal ancestor, prior to the migration of the Armenians and Maronites to Cyprus, estimated in the Late Bronze Age and Early Iron Age.
format	article
author	Irene Moutsouri Anna Keravnou Panayiotis Manoli Stefania Bertoncini Kyriaki Michailidou Vasilis Christofi Stavroulla Xenophontos Marios A Cariolou Evy Bashiardes
author_facet	Irene Moutsouri Anna Keravnou Panayiotis Manoli Stefania Bertoncini Kyriaki Michailidou Vasilis Christofi Stavroulla Xenophontos Marios A Cariolou Evy Bashiardes
author_sort	Irene Moutsouri
title	Comparative Y-chromosome analysis among Cypriots in the context of historical events and migrations.
title_short	Comparative Y-chromosome analysis among Cypriots in the context of historical events and migrations.
title_full	Comparative Y-chromosome analysis among Cypriots in the context of historical events and migrations.
title_fullStr	Comparative Y-chromosome analysis among Cypriots in the context of historical events and migrations.
title_full_unstemmed	Comparative Y-chromosome analysis among Cypriots in the context of historical events and migrations.
title_sort	comparative y-chromosome analysis among cypriots in the context of historical events and migrations.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1fca0ea311214be4ab7405ecb8e05253
work_keys_str_mv	AT irenemoutsouri comparativeychromosomeanalysisamongcypriotsinthecontextofhistoricaleventsandmigrations AT annakeravnou comparativeychromosomeanalysisamongcypriotsinthecontextofhistoricaleventsandmigrations AT panayiotismanoli comparativeychromosomeanalysisamongcypriotsinthecontextofhistoricaleventsandmigrations AT stefaniabertoncini comparativeychromosomeanalysisamongcypriotsinthecontextofhistoricaleventsandmigrations AT kyriakimichailidou comparativeychromosomeanalysisamongcypriotsinthecontextofhistoricaleventsandmigrations AT vasilischristofi comparativeychromosomeanalysisamongcypriotsinthecontextofhistoricaleventsandmigrations AT stavroullaxenophontos comparativeychromosomeanalysisamongcypriotsinthecontextofhistoricaleventsandmigrations AT mariosacariolou comparativeychromosomeanalysisamongcypriotsinthecontextofhistoricaleventsandmigrations AT evybashiardes comparativeychromosomeanalysisamongcypriotsinthecontextofhistoricaleventsandmigrations
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Comparative Y-chromosome analysis among Cypriots in the context of historical events and migrations.

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