Trimming Surface Sugars Protects <italic toggle="yes">Histoplasma</italic> from Immune Attack

ABSTRACT Dectin-1 is an essential innate immune receptor that recognizes β-glucans in fungal cell walls. Its importance is underscored by the mechanisms that fungal pathogens have evolved to avoid detection by this receptor. One such pathogen is Histoplasma capsulatum, and in a recent article in mBi...

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Autor principal:	Gordon D. Brown
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1fca0fda1b0f4abe913ce4c74e733f3c
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spelling	oai:doaj.org-article:1fca0fda1b0f4abe913ce4c74e733f3c2021-11-15T15:41:42ZTrimming Surface Sugars Protects <italic toggle="yes">Histoplasma</italic> from Immune Attack10.1128/mBio.00553-162150-7511https://doaj.org/article/1fca0fda1b0f4abe913ce4c74e733f3c2016-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00553-16https://doaj.org/toc/2150-7511ABSTRACT Dectin-1 is an essential innate immune receptor that recognizes β-glucans in fungal cell walls. Its importance is underscored by the mechanisms that fungal pathogens have evolved to avoid detection by this receptor. One such pathogen is Histoplasma capsulatum, and in a recent article in mBio, Rappleye’s group presented data showing that yeasts of this organism secrete a β-glucanase, Eng1, which acts to prune β-glucans that are exposed on the fungal cell surface [A. L. Garfoot et al., mBio 7(2):e01388-15, 2016, http://dx.doi.org/10.1128/mBio.01388-15]. The trimming of these sugars reduces immune recognition through Dectin-1 and subsequent inflammatory responses, enhancing the pathogenesis of H. capsulatum.Gordon D. BrownAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 2 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Gordon D. Brown Trimming Surface Sugars Protects <italic toggle="yes">Histoplasma</italic> from Immune Attack
description	ABSTRACT Dectin-1 is an essential innate immune receptor that recognizes β-glucans in fungal cell walls. Its importance is underscored by the mechanisms that fungal pathogens have evolved to avoid detection by this receptor. One such pathogen is Histoplasma capsulatum, and in a recent article in mBio, Rappleye’s group presented data showing that yeasts of this organism secrete a β-glucanase, Eng1, which acts to prune β-glucans that are exposed on the fungal cell surface [A. L. Garfoot et al., mBio 7(2):e01388-15, 2016, http://dx.doi.org/10.1128/mBio.01388-15]. The trimming of these sugars reduces immune recognition through Dectin-1 and subsequent inflammatory responses, enhancing the pathogenesis of H. capsulatum.
format	article
author	Gordon D. Brown
author_facet	Gordon D. Brown
author_sort	Gordon D. Brown
title	Trimming Surface Sugars Protects <italic toggle="yes">Histoplasma</italic> from Immune Attack
title_short	Trimming Surface Sugars Protects <italic toggle="yes">Histoplasma</italic> from Immune Attack
title_full	Trimming Surface Sugars Protects <italic toggle="yes">Histoplasma</italic> from Immune Attack
title_fullStr	Trimming Surface Sugars Protects <italic toggle="yes">Histoplasma</italic> from Immune Attack
title_full_unstemmed	Trimming Surface Sugars Protects <italic toggle="yes">Histoplasma</italic> from Immune Attack
title_sort	trimming surface sugars protects <italic toggle="yes">histoplasma</italic> from immune attack
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/1fca0fda1b0f4abe913ce4c74e733f3c
work_keys_str_mv	AT gordondbrown trimmingsurfacesugarsprotectsitalictoggleyeshistoplasmaitalicfromimmuneattack
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Trimming Surface Sugars Protects <italic toggle="yes">Histoplasma</italic> from Immune Attack

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