Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy

Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA3 levels and increases sensitivity to platinum age...

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Autores principales:	Katrina Kildey, Neha S. Gandhi, Katherine B. Sahin, Esha T. Shah, Eric Boittier, Pascal H. G. Duijf, Christopher Molloy, Joshua T. Burgess, Sam Beard, Emma Bolderson, Amila Suraweera, Derek J. Richard, Kenneth J. O’Byrne, Mark N. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1fca8dd3265e4aecb2ae8d295b050bfa
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spelling	oai:doaj.org-article:1fca8dd3265e4aecb2ae8d295b050bfa2021-12-02T14:49:10ZElevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy10.1038/s42003-021-02136-82399-3642https://doaj.org/article/1fca8dd3265e4aecb2ae8d295b050bfa2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02136-8https://doaj.org/toc/2399-3642Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA3 levels and increases sensitivity to platinum agents suggesting a therapeutic route.Katrina KildeyNeha S. GandhiKatherine B. SahinEsha T. ShahEric BoittierPascal H. G. DuijfChristopher MolloyJoshua T. BurgessSam BeardEmma BoldersonAmila SuraweeraDerek J. RichardKenneth J. O’ByrneMark N. AdamsNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Katrina Kildey Neha S. Gandhi Katherine B. Sahin Esha T. Shah Eric Boittier Pascal H. G. Duijf Christopher Molloy Joshua T. Burgess Sam Beard Emma Bolderson Amila Suraweera Derek J. Richard Kenneth J. O’Byrne Mark N. Adams Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
description	Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA3 levels and increases sensitivity to platinum agents suggesting a therapeutic route.
format	article
author	Katrina Kildey Neha S. Gandhi Katherine B. Sahin Esha T. Shah Eric Boittier Pascal H. G. Duijf Christopher Molloy Joshua T. Burgess Sam Beard Emma Bolderson Amila Suraweera Derek J. Richard Kenneth J. O’Byrne Mark N. Adams
author_facet	Katrina Kildey Neha S. Gandhi Katherine B. Sahin Esha T. Shah Eric Boittier Pascal H. G. Duijf Christopher Molloy Joshua T. Burgess Sam Beard Emma Bolderson Amila Suraweera Derek J. Richard Kenneth J. O’Byrne Mark N. Adams
author_sort	Katrina Kildey
title	Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
title_short	Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
title_full	Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
title_fullStr	Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
title_full_unstemmed	Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
title_sort	elevating cdca3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1fca8dd3265e4aecb2ae8d295b050bfa
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Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy

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