Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter

Tet-mediated DNA oxidation converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), which is essential to regulate different biological processes. Here the authors show that Tet1 and Tet2 regulate mesenchymal stem cell and bone homeostasis through demethylation of P2rX7 promoter.

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Autores principales:	Ruili Yang, Tingting Yu, Xiaoxing Kou, Xiang Gao, Chider Chen, Dawei Liu, Yanheng Zhou, Songtao Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fcc5914f79b40bcbd8f4c1b618f6f60
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spelling	oai:doaj.org-article:1fcc5914f79b40bcbd8f4c1b618f6f602021-12-02T17:32:47ZTet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter10.1038/s41467-018-04464-62041-1723https://doaj.org/article/1fcc5914f79b40bcbd8f4c1b618f6f602018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04464-6https://doaj.org/toc/2041-1723Tet-mediated DNA oxidation converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), which is essential to regulate different biological processes. Here the authors show that Tet1 and Tet2 regulate mesenchymal stem cell and bone homeostasis through demethylation of P2rX7 promoter.Ruili YangTingting YuXiaoxing KouXiang GaoChider ChenDawei LiuYanheng ZhouSongtao ShiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruili Yang Tingting Yu Xiaoxing Kou Xiang Gao Chider Chen Dawei Liu Yanheng Zhou Songtao Shi Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter
description	Tet-mediated DNA oxidation converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), which is essential to regulate different biological processes. Here the authors show that Tet1 and Tet2 regulate mesenchymal stem cell and bone homeostasis through demethylation of P2rX7 promoter.
format	article
author	Ruili Yang Tingting Yu Xiaoxing Kou Xiang Gao Chider Chen Dawei Liu Yanheng Zhou Songtao Shi
author_facet	Ruili Yang Tingting Yu Xiaoxing Kou Xiang Gao Chider Chen Dawei Liu Yanheng Zhou Songtao Shi
author_sort	Ruili Yang
title	Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter
title_short	Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter
title_full	Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter
title_fullStr	Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter
title_full_unstemmed	Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter
title_sort	tet1 and tet2 maintain mesenchymal stem cell homeostasis via demethylation of the p2rx7 promoter
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1fcc5914f79b40bcbd8f4c1b618f6f60
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Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter

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