The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes

Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.

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Autores principales:	Kay Oliver Schink, Kia Wee Tan, Hélène Spangenberg, Domenica Martorana, Marte Sneeggen, Virginie Stévenin, Jost Enninga, Coen Campsteijn, Camilla Raiborg, Harald Stenmark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fcda7e0cf7b4a7696d8bc77022c3d9e
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spelling	oai:doaj.org-article:1fcda7e0cf7b4a7696d8bc77022c3d9e2021-11-14T12:35:10ZThe phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes10.1038/s41467-021-26775-x2041-1723https://doaj.org/article/1fcda7e0cf7b4a7696d8bc77022c3d9e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26775-xhttps://doaj.org/toc/2041-1723Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.Kay Oliver SchinkKia Wee TanHélène SpangenbergDomenica MartoranaMarte SneeggenVirginie StéveninJost EnningaCoen CampsteijnCamilla RaiborgHarald StenmarkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kay Oliver Schink Kia Wee Tan Hélène Spangenberg Domenica Martorana Marte Sneeggen Virginie Stévenin Jost Enninga Coen Campsteijn Camilla Raiborg Harald Stenmark The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
description	Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.
format	article
author	Kay Oliver Schink Kia Wee Tan Hélène Spangenberg Domenica Martorana Marte Sneeggen Virginie Stévenin Jost Enninga Coen Campsteijn Camilla Raiborg Harald Stenmark
author_facet	Kay Oliver Schink Kia Wee Tan Hélène Spangenberg Domenica Martorana Marte Sneeggen Virginie Stévenin Jost Enninga Coen Campsteijn Camilla Raiborg Harald Stenmark
author_sort	Kay Oliver Schink
title	The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
title_short	The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
title_full	The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
title_fullStr	The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
title_full_unstemmed	The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
title_sort	phosphoinositide coincidence detector phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1fcda7e0cf7b4a7696d8bc77022c3d9e
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The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes

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