Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis

Lipeng Zhu,1 Yunlu Dai,1,2 Lizeng Gao,3 Qi Zhao1,2 1Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, People’s Republic of China; 2MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, People’s Republic of China; 3CAS Engineering...

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Autores principales:	Zhu L, Dai Y, Gao L, Zhao Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ros homeostasis nanozyme tumor microenvironment catalytic therapy photodynamic/photothermal therapy photothermal/photoacoustic imaging Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1fd609f602644609865468cbf0d67894
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spelling	oai:doaj.org-article:1fd609f602644609865468cbf0d678942021-12-02T16:11:30ZTumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis1178-2013https://doaj.org/article/1fd609f602644609865468cbf0d678942021-07-01T00:00:00Zhttps://www.dovepress.com/tumor-microenvironment-modulated-nanozymes-for-nir-ii-triggered-hypert-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Lipeng Zhu,1 Yunlu Dai,1,2 Lizeng Gao,3 Qi Zhao1,2 1Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, People’s Republic of China; 2MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, People’s Republic of China; 3CAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Science, Beijing, People’s Republic of ChinaCorrespondence: Qi ZhaoCancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, 999078, People’s Republic of ChinaEmail qizhao@um.edu.moPurpose: Reactive oxygen species (ROS) are a group of signaling biomolecules that play important roles in the cell cycle. When intracellular ROS homeostasis is disrupted, it can induce cellular necrosis and apoptosis. It is desirable to effectively cascade-amplifying ROS generation and weaken antioxidant defense for disrupting ROS homeostasis in tumor microenvironment (TME), which has been recognized as a novel and ideal antitumor strategy. Multifunctional nanozymes are highly promising agents for ROS-mediated therapy.Methods: This study constructed a novel theranostic nanoagent based on PEG@Cu2-xS@Ce6 nanozymes (PCCNs) through a facile one-step hydrothermal method. We systematically investigated the photodynamic therapy (PDT)/photothermal therapy (PTT) properties, catalytic therapy (CTT) and glutathione (GSH) depletion activities of PCCNs, antitumor efficacy induced by PCCNs in vitro and in vivo.Results: PCCNs generate singlet oxygen (1O2) with laser (660 nm) irradiation and use catalytic reactions to produce hydroxyl radical (•OH). Moreover, PCCNs show the high photothermal performance under NIR II 1064-nm laser irradiation, which can enhance CTT/PDT efficiencies to increase ROS generation. The properties of O2 evolution and GSH consumption of PCCNs achieve hypoxia-relieved PDT and destroy cellular antioxidant defense system respectively. The excellent antitumor efficacy in 4T1 tumor-bearing mice of PCCNs is achieved through disrupting ROS homeostasis-involved therapy under the guidance of photothermal/photoacoustic imaging.Conclusion: Our study provides a proof of concept of “all-in-one” nanozymes to eliminate tumors via disrupting ROS homeostasis.Keywords: ROS homeostasis, nanozyme, tumor microenvironment, catalytic therapy, photodynamic/photothermal therapy, photothermal/photoacoustic imagingZhu LDai YGao LZhao QDove Medical Pressarticleros homeostasisnanozymetumor microenvironmentcatalytic therapyphotodynamic/photothermal therapyphotothermal/photoacoustic imagingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 4559-4577 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ros homeostasis nanozyme tumor microenvironment catalytic therapy photodynamic/photothermal therapy photothermal/photoacoustic imaging Medicine (General) R5-920
spellingShingle	ros homeostasis nanozyme tumor microenvironment catalytic therapy photodynamic/photothermal therapy photothermal/photoacoustic imaging Medicine (General) R5-920 Zhu L Dai Y Gao L Zhao Q Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis
description	Lipeng Zhu,1 Yunlu Dai,1,2 Lizeng Gao,3 Qi Zhao1,2 1Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, People’s Republic of China; 2MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, People’s Republic of China; 3CAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Science, Beijing, People’s Republic of ChinaCorrespondence: Qi ZhaoCancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, 999078, People’s Republic of ChinaEmail qizhao@um.edu.moPurpose: Reactive oxygen species (ROS) are a group of signaling biomolecules that play important roles in the cell cycle. When intracellular ROS homeostasis is disrupted, it can induce cellular necrosis and apoptosis. It is desirable to effectively cascade-amplifying ROS generation and weaken antioxidant defense for disrupting ROS homeostasis in tumor microenvironment (TME), which has been recognized as a novel and ideal antitumor strategy. Multifunctional nanozymes are highly promising agents for ROS-mediated therapy.Methods: This study constructed a novel theranostic nanoagent based on PEG@Cu2-xS@Ce6 nanozymes (PCCNs) through a facile one-step hydrothermal method. We systematically investigated the photodynamic therapy (PDT)/photothermal therapy (PTT) properties, catalytic therapy (CTT) and glutathione (GSH) depletion activities of PCCNs, antitumor efficacy induced by PCCNs in vitro and in vivo.Results: PCCNs generate singlet oxygen (1O2) with laser (660 nm) irradiation and use catalytic reactions to produce hydroxyl radical (•OH). Moreover, PCCNs show the high photothermal performance under NIR II 1064-nm laser irradiation, which can enhance CTT/PDT efficiencies to increase ROS generation. The properties of O2 evolution and GSH consumption of PCCNs achieve hypoxia-relieved PDT and destroy cellular antioxidant defense system respectively. The excellent antitumor efficacy in 4T1 tumor-bearing mice of PCCNs is achieved through disrupting ROS homeostasis-involved therapy under the guidance of photothermal/photoacoustic imaging.Conclusion: Our study provides a proof of concept of “all-in-one” nanozymes to eliminate tumors via disrupting ROS homeostasis.Keywords: ROS homeostasis, nanozyme, tumor microenvironment, catalytic therapy, photodynamic/photothermal therapy, photothermal/photoacoustic imaging
format	article
author	Zhu L Dai Y Gao L Zhao Q
author_facet	Zhu L Dai Y Gao L Zhao Q
author_sort	Zhu L
title	Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis
title_short	Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis
title_full	Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis
title_fullStr	Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis
title_full_unstemmed	Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis
title_sort	tumor microenvironment-modulated nanozymes for nir-ii-triggered hyperthermia-enhanced photo-nanocatalytic therapy via disrupting ros homeostasis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1fd609f602644609865468cbf0d67894
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Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis

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