Total genetic contribution assessment across the human genome

Quantifying the effects of individual loci on the human phenome is a challenging task. Here, the authors introduce a modelling technique, TGCA, that assesses total genetic contribution per locus and apply this to UK Biobank phenotype domains, revealing top loci and links to tissue-specific gene expr...

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Autores principales: Ting Li, Zheng Ning, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Wenzheng Xu, Yipeng Wang, Kejun Ying, Yiwen Chen, Xia Shen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1fdc3181840949e299d2a885512f8054
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Sumario:Quantifying the effects of individual loci on the human phenome is a challenging task. Here, the authors introduce a modelling technique, TGCA, that assesses total genetic contribution per locus and apply this to UK Biobank phenotype domains, revealing top loci and links to tissue-specific gene expression.