Total genetic contribution assessment across the human genome

Quantifying the effects of individual loci on the human phenome is a challenging task. Here, the authors introduce a modelling technique, TGCA, that assesses total genetic contribution per locus and apply this to UK Biobank phenotype domains, revealing top loci and links to tissue-specific gene expr...

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Autores principales:	Ting Li, Zheng Ning, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Wenzheng Xu, Yipeng Wang, Kejun Ying, Yiwen Chen, Xia Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fdc3181840949e299d2a885512f8054
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spelling	oai:doaj.org-article:1fdc3181840949e299d2a885512f80542021-12-02T15:55:20ZTotal genetic contribution assessment across the human genome10.1038/s41467-021-23124-w2041-1723https://doaj.org/article/1fdc3181840949e299d2a885512f80542021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23124-whttps://doaj.org/toc/2041-1723Quantifying the effects of individual loci on the human phenome is a challenging task. Here, the authors introduce a modelling technique, TGCA, that assesses total genetic contribution per locus and apply this to UK Biobank phenotype domains, revealing top loci and links to tissue-specific gene expression.Ting LiZheng NingZhijian YangRanran ZhaiChenqing ZhengWenzheng XuYipeng WangKejun YingYiwen ChenXia ShenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ting Li Zheng Ning Zhijian Yang Ranran Zhai Chenqing Zheng Wenzheng Xu Yipeng Wang Kejun Ying Yiwen Chen Xia Shen Total genetic contribution assessment across the human genome
description	Quantifying the effects of individual loci on the human phenome is a challenging task. Here, the authors introduce a modelling technique, TGCA, that assesses total genetic contribution per locus and apply this to UK Biobank phenotype domains, revealing top loci and links to tissue-specific gene expression.
format	article
author	Ting Li Zheng Ning Zhijian Yang Ranran Zhai Chenqing Zheng Wenzheng Xu Yipeng Wang Kejun Ying Yiwen Chen Xia Shen
author_facet	Ting Li Zheng Ning Zhijian Yang Ranran Zhai Chenqing Zheng Wenzheng Xu Yipeng Wang Kejun Ying Yiwen Chen Xia Shen
author_sort	Ting Li
title	Total genetic contribution assessment across the human genome
title_short	Total genetic contribution assessment across the human genome
title_full	Total genetic contribution assessment across the human genome
title_fullStr	Total genetic contribution assessment across the human genome
title_full_unstemmed	Total genetic contribution assessment across the human genome
title_sort	total genetic contribution assessment across the human genome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1fdc3181840949e299d2a885512f8054
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Total genetic contribution assessment across the human genome

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