Single-cell differences in matrix gene expression do not predict matrix deposition

Regenerative tissue engineering with mesenchymal stem cells is hampered by bulk methods of assessing differentiation status and a general assumption that expression of individual markers of stem cell differentiation correlate with functional capacity. Here the authors debunk this assumption by apply...

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Autores principales:	Allison J. Cote, Claire M. McLeod, Megan J. Farrell, Patrick D. McClanahan, Margaret C. Dunagin, Arjun Raj, Robert L. Mauck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fdc868f1d42410980b0237dac4df543
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spelling	oai:doaj.org-article:1fdc868f1d42410980b0237dac4df5432021-12-02T16:49:57ZSingle-cell differences in matrix gene expression do not predict matrix deposition10.1038/ncomms108652041-1723https://doaj.org/article/1fdc868f1d42410980b0237dac4df5432016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10865https://doaj.org/toc/2041-1723Regenerative tissue engineering with mesenchymal stem cells is hampered by bulk methods of assessing differentiation status and a general assumption that expression of individual markers of stem cell differentiation correlate with functional capacity. Here the authors debunk this assumption by applying single-cell techniques to disassociate aggrecan mRNA abundance and matrix deposition.Allison J. CoteClaire M. McLeodMegan J. FarrellPatrick D. McClanahanMargaret C. DunaginArjun RajRobert L. MauckNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Allison J. Cote Claire M. McLeod Megan J. Farrell Patrick D. McClanahan Margaret C. Dunagin Arjun Raj Robert L. Mauck Single-cell differences in matrix gene expression do not predict matrix deposition
description	Regenerative tissue engineering with mesenchymal stem cells is hampered by bulk methods of assessing differentiation status and a general assumption that expression of individual markers of stem cell differentiation correlate with functional capacity. Here the authors debunk this assumption by applying single-cell techniques to disassociate aggrecan mRNA abundance and matrix deposition.
format	article
author	Allison J. Cote Claire M. McLeod Megan J. Farrell Patrick D. McClanahan Margaret C. Dunagin Arjun Raj Robert L. Mauck
author_facet	Allison J. Cote Claire M. McLeod Megan J. Farrell Patrick D. McClanahan Margaret C. Dunagin Arjun Raj Robert L. Mauck
author_sort	Allison J. Cote
title	Single-cell differences in matrix gene expression do not predict matrix deposition
title_short	Single-cell differences in matrix gene expression do not predict matrix deposition
title_full	Single-cell differences in matrix gene expression do not predict matrix deposition
title_fullStr	Single-cell differences in matrix gene expression do not predict matrix deposition
title_full_unstemmed	Single-cell differences in matrix gene expression do not predict matrix deposition
title_sort	single-cell differences in matrix gene expression do not predict matrix deposition
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1fdc868f1d42410980b0237dac4df543
work_keys_str_mv	AT allisonjcote singlecelldifferencesinmatrixgeneexpressiondonotpredictmatrixdeposition AT clairemmcleod singlecelldifferencesinmatrixgeneexpressiondonotpredictmatrixdeposition AT meganjfarrell singlecelldifferencesinmatrixgeneexpressiondonotpredictmatrixdeposition AT patrickdmcclanahan singlecelldifferencesinmatrixgeneexpressiondonotpredictmatrixdeposition AT margaretcdunagin singlecelldifferencesinmatrixgeneexpressiondonotpredictmatrixdeposition AT arjunraj singlecelldifferencesinmatrixgeneexpressiondonotpredictmatrixdeposition AT robertlmauck singlecelldifferencesinmatrixgeneexpressiondonotpredictmatrixdeposition
_version_	1718383143256326144

Single-cell differences in matrix gene expression do not predict matrix deposition

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