Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway

Metabolic reprogramming of smooth muscle cells (SMCs) plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH). Here, Dai et al. show that the glycolytic enzyme alpha-enolase contributes to this reprogramming, and that its inhibition limits SMC proliferation and disease p...

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Autores principales:	Jingbo Dai, Qiyuan Zhou, Jiwang Chen, Megan L. Rexius-Hall, Jalees Rehman, Guofei Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fe0c5edcc05495a850007b6679a029b
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spelling	oai:doaj.org-article:1fe0c5edcc05495a850007b6679a029b2021-12-02T16:49:39ZAlpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway10.1038/s41467-018-06376-x2041-1723https://doaj.org/article/1fe0c5edcc05495a850007b6679a029b2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06376-xhttps://doaj.org/toc/2041-1723Metabolic reprogramming of smooth muscle cells (SMCs) plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH). Here, Dai et al. show that the glycolytic enzyme alpha-enolase contributes to this reprogramming, and that its inhibition limits SMC proliferation and disease progression in animal models of PAH.Jingbo DaiQiyuan ZhouJiwang ChenMegan L. Rexius-HallJalees RehmanGuofei ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingbo Dai Qiyuan Zhou Jiwang Chen Megan L. Rexius-Hall Jalees Rehman Guofei Zhou Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
description	Metabolic reprogramming of smooth muscle cells (SMCs) plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH). Here, Dai et al. show that the glycolytic enzyme alpha-enolase contributes to this reprogramming, and that its inhibition limits SMC proliferation and disease progression in animal models of PAH.
format	article
author	Jingbo Dai Qiyuan Zhou Jiwang Chen Megan L. Rexius-Hall Jalees Rehman Guofei Zhou
author_facet	Jingbo Dai Qiyuan Zhou Jiwang Chen Megan L. Rexius-Hall Jalees Rehman Guofei Zhou
author_sort	Jingbo Dai
title	Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
title_short	Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
title_full	Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
title_fullStr	Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
title_full_unstemmed	Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
title_sort	alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the ampk-akt pathway
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1fe0c5edcc05495a850007b6679a029b
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Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway

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