Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy

Johan Karlsson, Saba Atefyekta, Martin Andersson Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden Abstract: The osseointegration capacity of bone-anchoring implants can be improved by the use of drugs that are administrated by an inb...

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Autores principales:	Karlsson J, Atefyekta S, Andersson M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1fe1aea8c1e24d928941eb2292570e6f
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spelling	oai:doaj.org-article:1fe1aea8c1e24d928941eb2292570e6f2021-12-02T02:38:21ZControlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy1178-2013https://doaj.org/article/1fe1aea8c1e24d928941eb2292570e6f2015-07-01T00:00:00Zhttp://www.dovepress.com/controlling-drug-delivery-kinetics-from-mesoporous-titania-thin-films--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Johan Karlsson, Saba Atefyekta, Martin Andersson Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden Abstract: The osseointegration capacity of bone-anchoring implants can be improved by the use of drugs that are administrated by an inbuilt drug delivery system. However, to attain superior control of drug delivery and to have the ability to administer drugs of varying size, including proteins, further material development of drug carriers is needed. Mesoporous materials have shown great potential in drug delivery applications to provide and maintain a drug concentration within the therapeutic window for the desired period of time. Moreover, drug delivery from coatings consisting of mesoporous titania has shown to be promising to improve healing of bone-anchoring implants. Here we report on how the delivery of an osteoporosis drug, alendronate, can be controlled by altering pore size and surface energy of mesoporous titania thin films. The pore size was varied from 3.4 nm to 7.2 nm by the use of different structure-directing templates and addition of a swelling agent. The surface energy was also altered by grafting dimethylsilane to the pore walls. The drug uptake and release profiles were monitored in situ using quartz crystal microbalance with dissipation (QCM-D) and it was shown that both pore size and surface energy had a profound effect on both the adsorption and release kinetics of alendronate. The QCM-D data provided evidence that the drug delivery from mesoporous titania films is controlled by a binding–diffusion mechanism. The yielded knowledge of release kinetics is crucial in order to improve the in vivo tissue response associated to therapeutic treatments. Keywords: mesoporous titania, controlled drug delivery, release kinetics, alendronate, QCM-DKarlsson JAtefyekta SAndersson MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4425-4436 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Karlsson J Atefyekta S Andersson M Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy
description	Johan Karlsson, Saba Atefyekta, Martin Andersson Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden Abstract: The osseointegration capacity of bone-anchoring implants can be improved by the use of drugs that are administrated by an inbuilt drug delivery system. However, to attain superior control of drug delivery and to have the ability to administer drugs of varying size, including proteins, further material development of drug carriers is needed. Mesoporous materials have shown great potential in drug delivery applications to provide and maintain a drug concentration within the therapeutic window for the desired period of time. Moreover, drug delivery from coatings consisting of mesoporous titania has shown to be promising to improve healing of bone-anchoring implants. Here we report on how the delivery of an osteoporosis drug, alendronate, can be controlled by altering pore size and surface energy of mesoporous titania thin films. The pore size was varied from 3.4 nm to 7.2 nm by the use of different structure-directing templates and addition of a swelling agent. The surface energy was also altered by grafting dimethylsilane to the pore walls. The drug uptake and release profiles were monitored in situ using quartz crystal microbalance with dissipation (QCM-D) and it was shown that both pore size and surface energy had a profound effect on both the adsorption and release kinetics of alendronate. The QCM-D data provided evidence that the drug delivery from mesoporous titania films is controlled by a binding–diffusion mechanism. The yielded knowledge of release kinetics is crucial in order to improve the in vivo tissue response associated to therapeutic treatments. Keywords: mesoporous titania, controlled drug delivery, release kinetics, alendronate, QCM-D
format	article
author	Karlsson J Atefyekta S Andersson M
author_facet	Karlsson J Atefyekta S Andersson M
author_sort	Karlsson J
title	Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy
title_short	Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy
title_full	Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy
title_fullStr	Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy
title_full_unstemmed	Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy
title_sort	controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/1fe1aea8c1e24d928941eb2292570e6f
work_keys_str_mv	AT karlssonj controllingdrugdeliverykineticsfrommesoporoustitaniathinfilmsbyporesizeandnbspsurfaceenergy AT atefyektas controllingdrugdeliverykineticsfrommesoporoustitaniathinfilmsbyporesizeandnbspsurfaceenergy AT anderssonm controllingdrugdeliverykineticsfrommesoporoustitaniathinfilmsbyporesizeandnbspsurfaceenergy
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Controlling drug delivery kinetics from mesoporous titania thin films by pore size and&nbsp;surface energy

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Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy