REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS

Abstract. Present work aims to investigate functioning of the regulatory T-cells with suppressor activity in surgical sepsis. It has been shown that the septic patients with decreased T cell proliferation are characterized by enhanced relative contents of СD4+СD25+ lymphocytes, including СD4-CD25hig...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	E. V. Kurganova, M. A. Tikhonova, E. I. Streltzova, A. A. Ostanin, E. R. Chernykh, V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	regulatory t-cells trn tr1 sepsis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1fe6989276b5426cbe2ab1ef69a30c81
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1fe6989276b5426cbe2ab1ef69a30c81
record_format	dspace
spelling	oai:doaj.org-article:1fe6989276b5426cbe2ab1ef69a30c812021-11-18T08:03:41ZREGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS1563-06252313-741X10.15789/1563-0625-2006-1-51-60https://doaj.org/article/1fe6989276b5426cbe2ab1ef69a30c812014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/426https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Present work aims to investigate functioning of the regulatory T-cells with suppressor activity in surgical sepsis. It has been shown that the septic patients with decreased T cell proliferation are characterized by enhanced relative contents of СD4+СD25+ lymphocytes, including СD4-CD25high. Moreover, a reverse correlation has been revealed between СD4+CD25+high and anti-CD3-induced proliferative response of mononuclear cells (MNC).Increased ratio of СD4+СD25+ cells is associated with arising suppressive activity of MNC, which is partially abrogated by addition of rIL-2. It should be noted that the depletion of CD25+ subpopulation is accompanied by increased T cell proliferation. Hence, a decrease in T cell proliferative activity in surgical sepsis is coupled with naturally occurring СD4+СD25+ regulatory T-cells (Trn).Furthermore, it has been demonstrated that the suppressive activity of MNCs in septic patients is mediated by soluble factors, in particular, IL-10. Indeed, septic patients are characterized by increased level of IL-10 production and enhanced number of CD4+IL-10+ T-cells. Addition of neutralizing anti-IL-10 antibody partially abrogated the suppressive activity of MNC supernatants. Thus, our study demonstrated that inducible regulatory T cells (Tr1) coupled to the naturally occurring СD4+СD25+ regulatory T-cells (Trn) actively contribute to genesis of immune pathology in sepsis.E. V. KurganovaM. A. TikhonovaE. I. StreltzovaA. A. OstaninE. R. ChernykhV. A. KozlovSPb RAACIarticleregulatory t-cellstrntr1sepsisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 1, Pp 51-60 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	regulatory t-cells trn tr1 sepsis Immunologic diseases. Allergy RC581-607
spellingShingle	regulatory t-cells trn tr1 sepsis Immunologic diseases. Allergy RC581-607 E. V. Kurganova M. A. Tikhonova E. I. Streltzova A. A. Ostanin E. R. Chernykh V. A. Kozlov REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS
description	Abstract. Present work aims to investigate functioning of the regulatory T-cells with suppressor activity in surgical sepsis. It has been shown that the septic patients with decreased T cell proliferation are characterized by enhanced relative contents of СD4+СD25+ lymphocytes, including СD4-CD25high. Moreover, a reverse correlation has been revealed between СD4+CD25+high and anti-CD3-induced proliferative response of mononuclear cells (MNC).Increased ratio of СD4+СD25+ cells is associated with arising suppressive activity of MNC, which is partially abrogated by addition of rIL-2. It should be noted that the depletion of CD25+ subpopulation is accompanied by increased T cell proliferation. Hence, a decrease in T cell proliferative activity in surgical sepsis is coupled with naturally occurring СD4+СD25+ regulatory T-cells (Trn).Furthermore, it has been demonstrated that the suppressive activity of MNCs in septic patients is mediated by soluble factors, in particular, IL-10. Indeed, septic patients are characterized by increased level of IL-10 production and enhanced number of CD4+IL-10+ T-cells. Addition of neutralizing anti-IL-10 antibody partially abrogated the suppressive activity of MNC supernatants. Thus, our study demonstrated that inducible regulatory T cells (Tr1) coupled to the naturally occurring СD4+СD25+ regulatory T-cells (Trn) actively contribute to genesis of immune pathology in sepsis.
format	article
author	E. V. Kurganova M. A. Tikhonova E. I. Streltzova A. A. Ostanin E. R. Chernykh V. A. Kozlov
author_facet	E. V. Kurganova M. A. Tikhonova E. I. Streltzova A. A. Ostanin E. R. Chernykh V. A. Kozlov
author_sort	E. V. Kurganova
title	REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS
title_short	REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS
title_full	REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS
title_fullStr	REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS
title_full_unstemmed	REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS
title_sort	regulatory tscells with suppressive activity in surgical sepsis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1fe6989276b5426cbe2ab1ef69a30c81
work_keys_str_mv	AT evkurganova regulatorytscellswithsuppressiveactivityinsurgicalsepsis AT matikhonova regulatorytscellswithsuppressiveactivityinsurgicalsepsis AT eistreltzova regulatorytscellswithsuppressiveactivityinsurgicalsepsis AT aaostanin regulatorytscellswithsuppressiveactivityinsurgicalsepsis AT erchernykh regulatorytscellswithsuppressiveactivityinsurgicalsepsis AT vakozlov regulatorytscellswithsuppressiveactivityinsurgicalsepsis
_version_	1718422467239739392

REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS

Ejemplares similares