A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression
SIRPa is most commonly known as a phagocytosis inhibitory receptor expressed by myeloid cells. Here the authors show SIRPa is expressed on a subset of CD8+ T cells with higher proliferative and effector activity during the chronic phase of the immune response to viral infection.
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Nature Portfolio
2019
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oai:doaj.org-article:1fe7158a38ec4c6c9bd116baa3bb1dee2021-12-02T17:02:17ZA functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression10.1038/s41467-019-08637-92041-1723https://doaj.org/article/1fe7158a38ec4c6c9bd116baa3bb1dee2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08637-9https://doaj.org/toc/2041-1723SIRPa is most commonly known as a phagocytosis inhibitory receptor expressed by myeloid cells. Here the authors show SIRPa is expressed on a subset of CD8+ T cells with higher proliferative and effector activity during the chronic phase of the immune response to viral infection.Lara M. MyersMichal Caspi TalLaughing Bear Torrez DulgeroffAaron B. CarmodyRonald J. MesserGunsagar GulatiYing Ying YiuMatthew M. StaronCesar Lopez AngelRahul SinhaMaxim MarkovicEdward A. PhamBenjamin FramAijaz AhmedAaron M. NewmanJeffrey S. GlennMark M. DavisSusan M. KaechIrving L. WeissmanKim J. HasenkrugNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lara M. Myers Michal Caspi Tal Laughing Bear Torrez Dulgeroff Aaron B. Carmody Ronald J. Messer Gunsagar Gulati Ying Ying Yiu Matthew M. Staron Cesar Lopez Angel Rahul Sinha Maxim Markovic Edward A. Pham Benjamin Fram Aijaz Ahmed Aaron M. Newman Jeffrey S. Glenn Mark M. Davis Susan M. Kaech Irving L. Weissman Kim J. Hasenkrug A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression |
| description |
SIRPa is most commonly known as a phagocytosis inhibitory receptor expressed by myeloid cells. Here the authors show SIRPa is expressed on a subset of CD8+ T cells with higher proliferative and effector activity during the chronic phase of the immune response to viral infection. |
| format |
article |
| author |
Lara M. Myers Michal Caspi Tal Laughing Bear Torrez Dulgeroff Aaron B. Carmody Ronald J. Messer Gunsagar Gulati Ying Ying Yiu Matthew M. Staron Cesar Lopez Angel Rahul Sinha Maxim Markovic Edward A. Pham Benjamin Fram Aijaz Ahmed Aaron M. Newman Jeffrey S. Glenn Mark M. Davis Susan M. Kaech Irving L. Weissman Kim J. Hasenkrug |
| author_facet |
Lara M. Myers Michal Caspi Tal Laughing Bear Torrez Dulgeroff Aaron B. Carmody Ronald J. Messer Gunsagar Gulati Ying Ying Yiu Matthew M. Staron Cesar Lopez Angel Rahul Sinha Maxim Markovic Edward A. Pham Benjamin Fram Aijaz Ahmed Aaron M. Newman Jeffrey S. Glenn Mark M. Davis Susan M. Kaech Irving L. Weissman Kim J. Hasenkrug |
| author_sort |
Lara M. Myers |
| title |
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression |
| title_short |
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression |
| title_full |
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression |
| title_fullStr |
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression |
| title_full_unstemmed |
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression |
| title_sort |
functional subset of cd8+ t cells during chronic exhaustion is defined by sirpα expression |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/1fe7158a38ec4c6c9bd116baa3bb1dee |
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