Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?

In psoriasis treatment, there is a high need to define meaningful endpoints and differences from the patient perspective to analyze patient-relevant differences of frequently used outcome methods for psoriasis under real-world conditions. A sample of 3116 patients from the German Psoriasis-Registry...

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Autores principales:	Natalia Kirsten, Stephan Rustenbach, Ralph von Kiedrowski, Christina Sorbe, Kristian Reich, Matthias Augustin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	psoriasis outcomes measurement preferences benefits registry Science Q
Acceso en línea:	https://doaj.org/article/1fecd4a7fbea48b1b84b0c4e46c7201e
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spelling	oai:doaj.org-article:1fecd4a7fbea48b1b84b0c4e46c7201e2021-11-25T18:10:42ZWhich PASI Outcome Is Most Relevant to the Patients in Real-World Care?10.3390/life111111512075-1729https://doaj.org/article/1fecd4a7fbea48b1b84b0c4e46c7201e2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1151https://doaj.org/toc/2075-1729In psoriasis treatment, there is a high need to define meaningful endpoints and differences from the patient perspective to analyze patient-relevant differences of frequently used outcome methods for psoriasis under real-world conditions. A sample of 3116 patients from the German Psoriasis-Registry PsoBest was analyzed for clinical as well as patient-reported outcomes (PRO) after 3- and 6-month treatment. The parameters PASI, DLQI, and PBI were intercorrelated and related to two anchoring variables: (1) patient satisfaction with treatment and (2) perceived complete clearance. Baseline data were as follows: PASI 10.5 ± 9.1, DLQI 12.4 ± 3.4, and PBI 2.7 ± 0.3. There was an almost linear relationship between “complete patient satisfaction” and the relative differences in PASI in the range from PASI 25 to PASI 90. However, there was no additional benefit between PASI 90 and PASI 100. The same finding resulted from the anchoring variable “perception of complete healing”. When related to DLQI outcomes, relative PASI changes as well as absolute changes and PASI at 3 and 6 months showed relevant differences between the PASI classes 25 to 90 but not between PASI 90 and PASI 100. Under real-world conditions, changes in PASI and DLQI reflect patient-relevant benefits.Natalia KirstenStephan RustenbachRalph von KiedrowskiChristina SorbeKristian ReichMatthias AugustinMDPI AGarticlepsoriasisoutcomes measurementpreferencesbenefitsregistryScienceQENLife, Vol 11, Iss 1151, p 1151 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis outcomes measurement preferences benefits registry Science Q
spellingShingle	psoriasis outcomes measurement preferences benefits registry Science Q Natalia Kirsten Stephan Rustenbach Ralph von Kiedrowski Christina Sorbe Kristian Reich Matthias Augustin Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?
description	In psoriasis treatment, there is a high need to define meaningful endpoints and differences from the patient perspective to analyze patient-relevant differences of frequently used outcome methods for psoriasis under real-world conditions. A sample of 3116 patients from the German Psoriasis-Registry PsoBest was analyzed for clinical as well as patient-reported outcomes (PRO) after 3- and 6-month treatment. The parameters PASI, DLQI, and PBI were intercorrelated and related to two anchoring variables: (1) patient satisfaction with treatment and (2) perceived complete clearance. Baseline data were as follows: PASI 10.5 ± 9.1, DLQI 12.4 ± 3.4, and PBI 2.7 ± 0.3. There was an almost linear relationship between “complete patient satisfaction” and the relative differences in PASI in the range from PASI 25 to PASI 90. However, there was no additional benefit between PASI 90 and PASI 100. The same finding resulted from the anchoring variable “perception of complete healing”. When related to DLQI outcomes, relative PASI changes as well as absolute changes and PASI at 3 and 6 months showed relevant differences between the PASI classes 25 to 90 but not between PASI 90 and PASI 100. Under real-world conditions, changes in PASI and DLQI reflect patient-relevant benefits.
format	article
author	Natalia Kirsten Stephan Rustenbach Ralph von Kiedrowski Christina Sorbe Kristian Reich Matthias Augustin
author_facet	Natalia Kirsten Stephan Rustenbach Ralph von Kiedrowski Christina Sorbe Kristian Reich Matthias Augustin
author_sort	Natalia Kirsten
title	Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?
title_short	Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?
title_full	Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?
title_fullStr	Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?
title_full_unstemmed	Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?
title_sort	which pasi outcome is most relevant to the patients in real-world care?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1fecd4a7fbea48b1b84b0c4e46c7201e
work_keys_str_mv	AT nataliakirsten whichpasioutcomeismostrelevanttothepatientsinrealworldcare AT stephanrustenbach whichpasioutcomeismostrelevanttothepatientsinrealworldcare AT ralphvonkiedrowski whichpasioutcomeismostrelevanttothepatientsinrealworldcare AT christinasorbe whichpasioutcomeismostrelevanttothepatientsinrealworldcare AT kristianreich whichpasioutcomeismostrelevanttothepatientsinrealworldcare AT matthiasaugustin whichpasioutcomeismostrelevanttothepatientsinrealworldcare
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Which PASI Outcome Is Most Relevant to the Patients in Real-World Care?

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