nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer

Ovarian cancers often display elevated TGF-β signaling but repressed miRNA expression. Here the authors identify that non-coding RNA nc886 expression is induced by TGF-β, which then binds to DICER and impairs miRNA maturation.

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Autores principales:	Ji-Hye Ahn, Hyun-Sung Lee, Ju-Seog Lee, Yeon-Su Lee, Jong-Lyul Park, Seon-Young Kim, Jung-Ah Hwang, Nawapol Kunkeaw, Sung Yun Jung, Tae Jin Kim, Kwang-Soo Lee, Sung Ho Jeon, Inhan Lee, Betty H. Johnson, Jung-Hye Choi, Yong Sun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1fef08d16d4f4920ab3eed8776cd77e0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:1fef08d16d4f4920ab3eed8776cd77e02021-12-02T13:27:23Znc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer10.1038/s41467-018-03556-72041-1723https://doaj.org/article/1fef08d16d4f4920ab3eed8776cd77e02018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03556-7https://doaj.org/toc/2041-1723Ovarian cancers often display elevated TGF-β signaling but repressed miRNA expression. Here the authors identify that non-coding RNA nc886 expression is induced by TGF-β, which then binds to DICER and impairs miRNA maturation.Ji-Hye AhnHyun-Sung LeeJu-Seog LeeYeon-Su LeeJong-Lyul ParkSeon-Young KimJung-Ah HwangNawapol KunkeawSung Yun JungTae Jin KimKwang-Soo LeeSung Ho JeonInhan LeeBetty H. JohnsonJung-Hye ChoiYong Sun LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ji-Hye Ahn Hyun-Sung Lee Ju-Seog Lee Yeon-Su Lee Jong-Lyul Park Seon-Young Kim Jung-Ah Hwang Nawapol Kunkeaw Sung Yun Jung Tae Jin Kim Kwang-Soo Lee Sung Ho Jeon Inhan Lee Betty H. Johnson Jung-Hye Choi Yong Sun Lee nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer
description	Ovarian cancers often display elevated TGF-β signaling but repressed miRNA expression. Here the authors identify that non-coding RNA nc886 expression is induced by TGF-β, which then binds to DICER and impairs miRNA maturation.
format	article
author	Ji-Hye Ahn Hyun-Sung Lee Ju-Seog Lee Yeon-Su Lee Jong-Lyul Park Seon-Young Kim Jung-Ah Hwang Nawapol Kunkeaw Sung Yun Jung Tae Jin Kim Kwang-Soo Lee Sung Ho Jeon Inhan Lee Betty H. Johnson Jung-Hye Choi Yong Sun Lee
author_facet	Ji-Hye Ahn Hyun-Sung Lee Ju-Seog Lee Yeon-Su Lee Jong-Lyul Park Seon-Young Kim Jung-Ah Hwang Nawapol Kunkeaw Sung Yun Jung Tae Jin Kim Kwang-Soo Lee Sung Ho Jeon Inhan Lee Betty H. Johnson Jung-Hye Choi Yong Sun Lee
author_sort	Ji-Hye Ahn
title	nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer
title_short	nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer
title_full	nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer
title_fullStr	nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer
title_full_unstemmed	nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer
title_sort	nc886 is induced by tgf-β and suppresses the microrna pathway in ovarian cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1fef08d16d4f4920ab3eed8776cd77e0
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nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer

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