Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)

Intestinal-type adenocarcinoma (ITAC) is a rare cancer of the nasal cavity and paranasal sinuses that occurs sporadically or secondary to exposure to occupational hazards, such as wood dust and leather. Eukaryotic translation initiation factors have been described as promising targets for novel canc...

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Autores principales:	Christoph Schatz, Susanne Sprung, Volker Schartinger, Helena Codina-Martínez, Matt Lechner, Mario Hermsen, Johannes Haybaeck
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sinonasal adenocarcinoma of the intestinal type (ITAC) translation factors biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1ff0ba05d48d4fcf9a956d515273c8dd
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spelling	oai:doaj.org-article:1ff0ba05d48d4fcf9a956d515273c8dd2021-11-25T17:02:09ZDysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)10.3390/cancers132256492072-6694https://doaj.org/article/1ff0ba05d48d4fcf9a956d515273c8dd2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5649https://doaj.org/toc/2072-6694Intestinal-type adenocarcinoma (ITAC) is a rare cancer of the nasal cavity and paranasal sinuses that occurs sporadically or secondary to exposure to occupational hazards, such as wood dust and leather. Eukaryotic translation initiation factors have been described as promising targets for novel cancer treatments in many cancers, but hardly anything is known about these factors in ITAC. Here we performed in silico analyses, evaluated the protein levels of EIF2S1, EIF5A and EIF6 in tumour samples and non-neoplastic tissue controls obtained from 145 patients, and correlated these results with clinical outcome data, including tumour site, stage, adjuvant radiotherapy and survival. In silico analyses revealed significant upregulation of the translation factors EIF6 (ITGB4BP), EIF5, EIF2S1 and EIF2S2 (<i>p</i> < 0.05) with a higher arithmetic mean expression in ITAC compared to non-neoplastic tissue (NNT). Immunohistochemical analyses using antibodies against EIF2S1 and EIF6 confirmed a significantly different expression at the protein level (<i>p</i> < 0.05). In conclusion, this work identifies the eukaryotic translation initiation factors EIF2S1 and EIF6 to be significantly upregulated in ITAC. As these factors have been described as promising therapeutic targets in other cancers, this work identifies candidate therapeutic targets in this rare but often deadly cancer.Christoph SchatzSusanne SprungVolker SchartingerHelena Codina-MartínezMatt LechnerMario HermsenJohannes HaybaeckMDPI AGarticlesinonasal adenocarcinoma of the intestinal type (ITAC)translation factorsbiomarkersNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5649, p 5649 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sinonasal adenocarcinoma of the intestinal type (ITAC) translation factors biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	sinonasal adenocarcinoma of the intestinal type (ITAC) translation factors biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Christoph Schatz Susanne Sprung Volker Schartinger Helena Codina-Martínez Matt Lechner Mario Hermsen Johannes Haybaeck Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)
description	Intestinal-type adenocarcinoma (ITAC) is a rare cancer of the nasal cavity and paranasal sinuses that occurs sporadically or secondary to exposure to occupational hazards, such as wood dust and leather. Eukaryotic translation initiation factors have been described as promising targets for novel cancer treatments in many cancers, but hardly anything is known about these factors in ITAC. Here we performed in silico analyses, evaluated the protein levels of EIF2S1, EIF5A and EIF6 in tumour samples and non-neoplastic tissue controls obtained from 145 patients, and correlated these results with clinical outcome data, including tumour site, stage, adjuvant radiotherapy and survival. In silico analyses revealed significant upregulation of the translation factors EIF6 (ITGB4BP), EIF5, EIF2S1 and EIF2S2 (<i>p</i> < 0.05) with a higher arithmetic mean expression in ITAC compared to non-neoplastic tissue (NNT). Immunohistochemical analyses using antibodies against EIF2S1 and EIF6 confirmed a significantly different expression at the protein level (<i>p</i> < 0.05). In conclusion, this work identifies the eukaryotic translation initiation factors EIF2S1 and EIF6 to be significantly upregulated in ITAC. As these factors have been described as promising therapeutic targets in other cancers, this work identifies candidate therapeutic targets in this rare but often deadly cancer.
format	article
author	Christoph Schatz Susanne Sprung Volker Schartinger Helena Codina-Martínez Matt Lechner Mario Hermsen Johannes Haybaeck
author_facet	Christoph Schatz Susanne Sprung Volker Schartinger Helena Codina-Martínez Matt Lechner Mario Hermsen Johannes Haybaeck
author_sort	Christoph Schatz
title	Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)
title_short	Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)
title_full	Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)
title_fullStr	Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)
title_full_unstemmed	Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)
title_sort	dysregulation of translation factors eif2s1, eif5a and eif6 in intestinal-type adenocarcinoma (itac)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1ff0ba05d48d4fcf9a956d515273c8dd
work_keys_str_mv	AT christophschatz dysregulationoftranslationfactorseif2s1eif5aandeif6inintestinaltypeadenocarcinomaitac AT susannesprung dysregulationoftranslationfactorseif2s1eif5aandeif6inintestinaltypeadenocarcinomaitac AT volkerschartinger dysregulationoftranslationfactorseif2s1eif5aandeif6inintestinaltypeadenocarcinomaitac AT helenacodinamartinez dysregulationoftranslationfactorseif2s1eif5aandeif6inintestinaltypeadenocarcinomaitac AT mattlechner dysregulationoftranslationfactorseif2s1eif5aandeif6inintestinaltypeadenocarcinomaitac AT mariohermsen dysregulationoftranslationfactorseif2s1eif5aandeif6inintestinaltypeadenocarcinomaitac AT johanneshaybaeck dysregulationoftranslationfactorseif2s1eif5aandeif6inintestinaltypeadenocarcinomaitac
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Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)

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