Floor vibrations for motivation and feedback in the rat vibration actuating search task.

Motivating rodents to perform cognitive tasks often relies on the application of aversive stimuli. The Vibration Actuating Search Task (VAST) is a novel open-field task in which gradient floor vibration provides motivation for the rodent to navigate in the direction of diminishing vibration to an un...

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Autores principales:	Darian Lawrence-Sidebottom, Michelle A Schmidt, Daniel O Harvey, Hans P A Van Dongen, Christopher J Davis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ff0f0bedacf4230a24886fea0e383a2
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spelling	oai:doaj.org-article:1ff0f0bedacf4230a24886fea0e383a22021-12-02T20:17:27ZFloor vibrations for motivation and feedback in the rat vibration actuating search task.1932-620310.1371/journal.pone.0257980https://doaj.org/article/1ff0f0bedacf4230a24886fea0e383a22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257980https://doaj.org/toc/1932-6203Motivating rodents to perform cognitive tasks often relies on the application of aversive stimuli. The Vibration Actuating Search Task (VAST) is a novel open-field task in which gradient floor vibration provides motivation for the rodent to navigate in the direction of diminishing vibration to an unmarked target destination. Using floor vibration as a motivational stimulus may overcome several of the potential confounds associated with stimuli used in other tasks. In a series of three experiments, we determined whether (1) rats exhibit place preference for floor vibration over other aversive stimuli (i.e., water, foot shock, and bright light), (2) exposure to floor vibration is associated with a lower corticosterone response than exposure to these other stimuli, (3) rats successfully acquire the VAST, and (4) VAST performance is sensitive to 6 h of sleep deprivation (SD). Our results showed that rats exhibited place preference for vibration over water, foot shock, and bright light environments, and that corticosterone levels were lower in rats exposed to vibration than those exposed to water. VAST performance also significantly improved over two days of testing for some metrics, and SD impaired VAST performance. Overall, we conclude that (1) rats exhibit place preference for vibration over other stimuli commonly used to motivate task performance, (2) the vibrations employed by the VAST produce lower concentrations of circulating corticosterone than forced swimming, (3) rats can learn to use gradient floor vibration as a mode of performance feedback within two days of testing, and (4) VAST performance is substantially impaired by SD. Thus, the VAST is an effective and practical testbed for studying the mechanisms by which SD causes deficits in feedback-dependent decision making.Darian Lawrence-SidebottomMichelle A SchmidtDaniel O HarveyHans P A Van DongenChristopher J DavisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257980 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Darian Lawrence-Sidebottom Michelle A Schmidt Daniel O Harvey Hans P A Van Dongen Christopher J Davis Floor vibrations for motivation and feedback in the rat vibration actuating search task.
description	Motivating rodents to perform cognitive tasks often relies on the application of aversive stimuli. The Vibration Actuating Search Task (VAST) is a novel open-field task in which gradient floor vibration provides motivation for the rodent to navigate in the direction of diminishing vibration to an unmarked target destination. Using floor vibration as a motivational stimulus may overcome several of the potential confounds associated with stimuli used in other tasks. In a series of three experiments, we determined whether (1) rats exhibit place preference for floor vibration over other aversive stimuli (i.e., water, foot shock, and bright light), (2) exposure to floor vibration is associated with a lower corticosterone response than exposure to these other stimuli, (3) rats successfully acquire the VAST, and (4) VAST performance is sensitive to 6 h of sleep deprivation (SD). Our results showed that rats exhibited place preference for vibration over water, foot shock, and bright light environments, and that corticosterone levels were lower in rats exposed to vibration than those exposed to water. VAST performance also significantly improved over two days of testing for some metrics, and SD impaired VAST performance. Overall, we conclude that (1) rats exhibit place preference for vibration over other stimuli commonly used to motivate task performance, (2) the vibrations employed by the VAST produce lower concentrations of circulating corticosterone than forced swimming, (3) rats can learn to use gradient floor vibration as a mode of performance feedback within two days of testing, and (4) VAST performance is substantially impaired by SD. Thus, the VAST is an effective and practical testbed for studying the mechanisms by which SD causes deficits in feedback-dependent decision making.
format	article
author	Darian Lawrence-Sidebottom Michelle A Schmidt Daniel O Harvey Hans P A Van Dongen Christopher J Davis
author_facet	Darian Lawrence-Sidebottom Michelle A Schmidt Daniel O Harvey Hans P A Van Dongen Christopher J Davis
author_sort	Darian Lawrence-Sidebottom
title	Floor vibrations for motivation and feedback in the rat vibration actuating search task.
title_short	Floor vibrations for motivation and feedback in the rat vibration actuating search task.
title_full	Floor vibrations for motivation and feedback in the rat vibration actuating search task.
title_fullStr	Floor vibrations for motivation and feedback in the rat vibration actuating search task.
title_full_unstemmed	Floor vibrations for motivation and feedback in the rat vibration actuating search task.
title_sort	floor vibrations for motivation and feedback in the rat vibration actuating search task.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1ff0f0bedacf4230a24886fea0e383a2
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Floor vibrations for motivation and feedback in the rat vibration actuating search task.

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