Klotho, stem cells, and aging

Ao Bian,1,2 Javier A Neyra,3 Ming Zhan,4 Ming Chang Hu1,3 1Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing, People&...

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Autores principales:	Bian A, Neyra JA, Zhan M, Hu MC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Aging Cell senescence Klotho Stem cells Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/1ff23e9e4abe41e38f593149e89688fd
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spelling	oai:doaj.org-article:1ff23e9e4abe41e38f593149e89688fd2021-12-02T02:59:43ZKlotho, stem cells, and aging1178-1998https://doaj.org/article/1ff23e9e4abe41e38f593149e89688fd2015-08-01T00:00:00Zhttps://www.dovepress.com/klotho-stem-cells-and-aging-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ao Bian,1,2 Javier A Neyra,3 Ming Zhan,4 Ming Chang Hu1,3 1Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 3Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 4Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX, USA Abstract: Aging is an inevitable and progressive biological process involving dysfunction and eventually destruction of every tissue and organ. This process is driven by a tightly regulated and complex interplay between genetic and acquired factors. Klotho is an antiaging gene encoding a single-pass transmembrane protein, klotho, which serves as an aging suppressor through a wide variety of mechanisms, such as antioxidation, antisenescence, antiautophagy, and modulation of many signaling pathways, including insulin-like growth factor and Wnt. Klotho deficiency activates Wnt expression and activity contributing to senescence and depletion of stem cells, which consequently triggers tissue atrophy and fibrosis. In contrast, the klotho protein was shown to suppress Wnt-signaling transduction, and inhibit cell senescence and preserve stem cells. A better understanding of the potential effects of klotho on stem cells could offer novel insights into the cellular and molecular mechanisms of klotho deficiency-related aging and disease. The klotho protein may be a promising therapeutic agent for aging and aging-related disorders. Keywords: aging, cell senescence, klotho, stem cells, Wnt  Bian ANeyra JAZhan MHu MCDove Medical PressarticleAgingCell senescenceKlothoStem cellsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 1233-1243 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aging Cell senescence Klotho Stem cells Geriatrics RC952-954.6
spellingShingle	Aging Cell senescence Klotho Stem cells Geriatrics RC952-954.6 Bian A Neyra JA Zhan M Hu MC Klotho, stem cells, and aging
description	Ao Bian,1,2 Javier A Neyra,3 Ming Zhan,4 Ming Chang Hu1,3 1Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 3Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 4Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX, USA Abstract: Aging is an inevitable and progressive biological process involving dysfunction and eventually destruction of every tissue and organ. This process is driven by a tightly regulated and complex interplay between genetic and acquired factors. Klotho is an antiaging gene encoding a single-pass transmembrane protein, klotho, which serves as an aging suppressor through a wide variety of mechanisms, such as antioxidation, antisenescence, antiautophagy, and modulation of many signaling pathways, including insulin-like growth factor and Wnt. Klotho deficiency activates Wnt expression and activity contributing to senescence and depletion of stem cells, which consequently triggers tissue atrophy and fibrosis. In contrast, the klotho protein was shown to suppress Wnt-signaling transduction, and inhibit cell senescence and preserve stem cells. A better understanding of the potential effects of klotho on stem cells could offer novel insights into the cellular and molecular mechanisms of klotho deficiency-related aging and disease. The klotho protein may be a promising therapeutic agent for aging and aging-related disorders. Keywords: aging, cell senescence, klotho, stem cells, Wnt
format	article
author	Bian A Neyra JA Zhan M Hu MC
author_facet	Bian A Neyra JA Zhan M Hu MC
author_sort	Bian A
title	Klotho, stem cells, and aging
title_short	Klotho, stem cells, and aging
title_full	Klotho, stem cells, and aging
title_fullStr	Klotho, stem cells, and aging
title_full_unstemmed	Klotho, stem cells, and aging
title_sort	klotho, stem cells, and aging
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/1ff23e9e4abe41e38f593149e89688fd
work_keys_str_mv	AT biana klothostemcellsandaging AT neyraja klothostemcellsandaging AT zhanm klothostemcellsandaging AT humc klothostemcellsandaging
_version_	1718401967959572480

Klotho, stem cells, and aging

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