Assumed white blood cell count of 8,000 cells/μL overestimates malaria parasite density in the Brazilian Amazon.

Quantification of parasite density is an important component in the diagnosis of malaria infection. The accuracy of this estimation varies according to the method used. The aim of this study was to assess the agreement between the parasite density values obtained with the assumed value of 8,000 cell...

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Autores principales:	Eduardo R Alves-Junior, Luciano T Gomes, Daniele Ribatski-Silva, Clebson Rodrigues J Mendes, Fabio A Leal-Santos, Luciano R Simões, Marcia Beatriz C Mello, Cor Jesus F Fontes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ff4c48faf514995a8910c056697ca06
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spelling	oai:doaj.org-article:1ff4c48faf514995a8910c056697ca062021-11-18T08:24:03ZAssumed white blood cell count of 8,000 cells/μL overestimates malaria parasite density in the Brazilian Amazon.1932-620310.1371/journal.pone.0094193https://doaj.org/article/1ff4c48faf514995a8910c056697ca062014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24721983/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Quantification of parasite density is an important component in the diagnosis of malaria infection. The accuracy of this estimation varies according to the method used. The aim of this study was to assess the agreement between the parasite density values obtained with the assumed value of 8,000 cells/μL and the automated WBC count. Moreover, the same comparative analysis was carried out for other assumed values of WBCs. The study was carried out in Brazil with 403 malaria patients who were infected in different endemic areas of the Brazilian Amazon. The use of a fixed WBC count of 8,000 cells/μL to quantify parasite density in malaria patients led to overestimated parasitemia and resulted in low reliability when compared to the automated WBC count. Assumed values ranging between 5,000 and 6,000 cells/μL, and 5,500 cells/μL in particular, showed higher reliability and more similar values of parasite density when compared between the 2 methods. The findings show that assumed WBC count of 5,500 cells/μL could lead to a more accurate estimation of parasite density for malaria patients in this endemic region.Eduardo R Alves-JuniorLuciano T GomesDaniele Ribatski-SilvaClebson Rodrigues J MendesFabio A Leal-SantosLuciano R SimõesMarcia Beatriz C MelloCor Jesus F FontesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e94193 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eduardo R Alves-Junior Luciano T Gomes Daniele Ribatski-Silva Clebson Rodrigues J Mendes Fabio A Leal-Santos Luciano R Simões Marcia Beatriz C Mello Cor Jesus F Fontes Assumed white blood cell count of 8,000 cells/μL overestimates malaria parasite density in the Brazilian Amazon.
description	Quantification of parasite density is an important component in the diagnosis of malaria infection. The accuracy of this estimation varies according to the method used. The aim of this study was to assess the agreement between the parasite density values obtained with the assumed value of 8,000 cells/μL and the automated WBC count. Moreover, the same comparative analysis was carried out for other assumed values of WBCs. The study was carried out in Brazil with 403 malaria patients who were infected in different endemic areas of the Brazilian Amazon. The use of a fixed WBC count of 8,000 cells/μL to quantify parasite density in malaria patients led to overestimated parasitemia and resulted in low reliability when compared to the automated WBC count. Assumed values ranging between 5,000 and 6,000 cells/μL, and 5,500 cells/μL in particular, showed higher reliability and more similar values of parasite density when compared between the 2 methods. The findings show that assumed WBC count of 5,500 cells/μL could lead to a more accurate estimation of parasite density for malaria patients in this endemic region.
format	article
author	Eduardo R Alves-Junior Luciano T Gomes Daniele Ribatski-Silva Clebson Rodrigues J Mendes Fabio A Leal-Santos Luciano R Simões Marcia Beatriz C Mello Cor Jesus F Fontes
author_facet	Eduardo R Alves-Junior Luciano T Gomes Daniele Ribatski-Silva Clebson Rodrigues J Mendes Fabio A Leal-Santos Luciano R Simões Marcia Beatriz C Mello Cor Jesus F Fontes
author_sort	Eduardo R Alves-Junior
title	Assumed white blood cell count of 8,000 cells/μL overestimates malaria parasite density in the Brazilian Amazon.
title_short	Assumed white blood cell count of 8,000 cells/μL overestimates malaria parasite density in the Brazilian Amazon.
title_full	Assumed white blood cell count of 8,000 cells/μL overestimates malaria parasite density in the Brazilian Amazon.
title_fullStr	Assumed white blood cell count of 8,000 cells/μL overestimates malaria parasite density in the Brazilian Amazon.
title_full_unstemmed	Assumed white blood cell count of 8,000 cells/μL overestimates malaria parasite density in the Brazilian Amazon.
title_sort	assumed white blood cell count of 8,000 cells/μl overestimates malaria parasite density in the brazilian amazon.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1ff4c48faf514995a8910c056697ca06
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Assumed white blood cell count of 8,000 cells/μL overestimates malaria parasite density in the Brazilian Amazon.

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