Delayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing

Background: Glioblastomas are malignant, often incurable brain tumors. Reliable discrimination between recurrent disease and treatment changes is a significant challenge. Prior work has suggested glioblastoma FDG PET conspicuity is improved at delayed time points vs. conventional imaging times. This...

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Autores principales:	Jason Michael Johnson, Melissa M. Chen, Eric M. Rohren, Sujit Prabhu, Beth Chasen, Osama Mawlawi, Ho-Ling Liu, Maria Kristine Gule-Monroe
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	PET CT scan delayed imaging glioblastoma FDG (18F-fluorodeoxyglucose)-PET/CT brain tumor Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1ff55c1dc5b34c658800dd316d1fe54e
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spelling	oai:doaj.org-article:1ff55c1dc5b34c658800dd316d1fe54e2021-11-16T05:57:01ZDelayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing1664-229510.3389/fneur.2021.740280https://doaj.org/article/1ff55c1dc5b34c658800dd316d1fe54e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.740280/fullhttps://doaj.org/toc/1664-2295Background: Glioblastomas are malignant, often incurable brain tumors. Reliable discrimination between recurrent disease and treatment changes is a significant challenge. Prior work has suggested glioblastoma FDG PET conspicuity is improved at delayed time points vs. conventional imaging times. This study aimed to determine the ideal FDG imaging time point in a population of untreated glioblastomas in preparation for future trials involving the non-invasive assessment of true progression vs. pseudoprogression in glioblastoma.Methods: Sixteen pre-treatment adults with suspected glioblastoma received FDG PET at 1, 5, and 8 h post-FDG injection within the 3 days prior to surgery. Maximum standard uptake values were measured at each timepoint for the central enhancing component of the lesion and the contralateral normal-appearing brain.Results: Sixteen patients (nine male) had pathology confirmed IDH-wildtype, glioblastoma. Our results revealed statistically significant improvements in the maximum standardized uptake values and subjective conspicuity of glioblastomas at later time points compared to the conventional (1 h time point). The tumor to background ratio at 1, 5, and 8 h was 1.4 ± 0.4, 1.8 ± 0.5, and 2.1 ± 0.6, respectively. This was statistically significant for the 5 h time point over the 1 h time point (p > 0.001), the 8 h time point over the 1 h time point (p = 0.026), and the 8 h time point over the 5 h time point (p = 0.036).Conclusions: Our findings demonstrate that delayed imaging time point provides superior conspicuity of glioblastoma compared to conventional imaging. Further research based on these results may translate into improvements in the determination of true progression from pseudoprogression.Jason Michael JohnsonMelissa M. ChenEric M. RohrenSujit PrabhuBeth ChasenOsama MawlawiHo-Ling LiuMaria Kristine Gule-MonroeFrontiers Media S.A.articlePET CT scandelayed imagingglioblastomaFDG (18F-fluorodeoxyglucose)-PET/CTbrain tumorNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PET CT scan delayed imaging glioblastoma FDG (18F-fluorodeoxyglucose)-PET/CT brain tumor Neurology. Diseases of the nervous system RC346-429
spellingShingle	PET CT scan delayed imaging glioblastoma FDG (18F-fluorodeoxyglucose)-PET/CT brain tumor Neurology. Diseases of the nervous system RC346-429 Jason Michael Johnson Melissa M. Chen Eric M. Rohren Sujit Prabhu Beth Chasen Osama Mawlawi Ho-Ling Liu Maria Kristine Gule-Monroe Delayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing
description	Background: Glioblastomas are malignant, often incurable brain tumors. Reliable discrimination between recurrent disease and treatment changes is a significant challenge. Prior work has suggested glioblastoma FDG PET conspicuity is improved at delayed time points vs. conventional imaging times. This study aimed to determine the ideal FDG imaging time point in a population of untreated glioblastomas in preparation for future trials involving the non-invasive assessment of true progression vs. pseudoprogression in glioblastoma.Methods: Sixteen pre-treatment adults with suspected glioblastoma received FDG PET at 1, 5, and 8 h post-FDG injection within the 3 days prior to surgery. Maximum standard uptake values were measured at each timepoint for the central enhancing component of the lesion and the contralateral normal-appearing brain.Results: Sixteen patients (nine male) had pathology confirmed IDH-wildtype, glioblastoma. Our results revealed statistically significant improvements in the maximum standardized uptake values and subjective conspicuity of glioblastomas at later time points compared to the conventional (1 h time point). The tumor to background ratio at 1, 5, and 8 h was 1.4 ± 0.4, 1.8 ± 0.5, and 2.1 ± 0.6, respectively. This was statistically significant for the 5 h time point over the 1 h time point (p > 0.001), the 8 h time point over the 1 h time point (p = 0.026), and the 8 h time point over the 5 h time point (p = 0.036).Conclusions: Our findings demonstrate that delayed imaging time point provides superior conspicuity of glioblastoma compared to conventional imaging. Further research based on these results may translate into improvements in the determination of true progression from pseudoprogression.
format	article
author	Jason Michael Johnson Melissa M. Chen Eric M. Rohren Sujit Prabhu Beth Chasen Osama Mawlawi Ho-Ling Liu Maria Kristine Gule-Monroe
author_facet	Jason Michael Johnson Melissa M. Chen Eric M. Rohren Sujit Prabhu Beth Chasen Osama Mawlawi Ho-Ling Liu Maria Kristine Gule-Monroe
author_sort	Jason Michael Johnson
title	Delayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing
title_short	Delayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing
title_full	Delayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing
title_fullStr	Delayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing
title_full_unstemmed	Delayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing
title_sort	delayed fdg pet provides superior glioblastoma conspicuity compared to conventional image timing
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1ff55c1dc5b34c658800dd316d1fe54e
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Delayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing

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