Functional connectivity in the first year of life in infants at risk for autism spectrum disorder: an EEG study.

In the field of autism research, recent work has been devoted to studying both behavioral and neural markers that may aide in early identification of autism spectrum disorder (ASD). These studies have often tested infants who have a significant family history of autism spectrum disorder, given the i...

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Autores principales:	Giulia Righi, Adrienne L Tierney, Helen Tager-Flusberg, Charles A Nelson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ff9c6b4a8b043668068927ce68c7ee2
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spelling	oai:doaj.org-article:1ff9c6b4a8b043668068927ce68c7ee22021-11-25T06:03:57ZFunctional connectivity in the first year of life in infants at risk for autism spectrum disorder: an EEG study.1932-620310.1371/journal.pone.0105176https://doaj.org/article/1ff9c6b4a8b043668068927ce68c7ee22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25140874/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203In the field of autism research, recent work has been devoted to studying both behavioral and neural markers that may aide in early identification of autism spectrum disorder (ASD). These studies have often tested infants who have a significant family history of autism spectrum disorder, given the increased prevalence observed among such infants. In the present study we tested infants at high- and low-risk for ASD (based on having an older sibling diagnosed with the disorder or not) at 6- and 12-months-of-age. We computed intrahemispheric linear coherence between anterior and posterior sites as a measure of neural functional connectivity derived from electroencephalography while the infants were listening to speech sounds. We found that by 12-months-of-age infants at risk for ASD showed reduced functional connectivity compared to low risk infants. Moreover, by 12-months-of-age infants later diagnosed with ASD showed reduced functional connectivity, compared to both infants at low risk for the disorder and infants at high risk who were not later diagnosed with ASD. Significant differences in functional connectivity were also found between low-risk infants and high-risk infants who did not go onto develop ASD. These results demonstrate that reduced functional connectivity appears to be related to genetic vulnerability for ASD. Moreover, they provide further evidence that ASD is broadly characterized by differences in neural integration that emerge during the first year of life.Giulia RighiAdrienne L TierneyHelen Tager-FlusbergCharles A NelsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105176 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giulia Righi Adrienne L Tierney Helen Tager-Flusberg Charles A Nelson Functional connectivity in the first year of life in infants at risk for autism spectrum disorder: an EEG study.
description	In the field of autism research, recent work has been devoted to studying both behavioral and neural markers that may aide in early identification of autism spectrum disorder (ASD). These studies have often tested infants who have a significant family history of autism spectrum disorder, given the increased prevalence observed among such infants. In the present study we tested infants at high- and low-risk for ASD (based on having an older sibling diagnosed with the disorder or not) at 6- and 12-months-of-age. We computed intrahemispheric linear coherence between anterior and posterior sites as a measure of neural functional connectivity derived from electroencephalography while the infants were listening to speech sounds. We found that by 12-months-of-age infants at risk for ASD showed reduced functional connectivity compared to low risk infants. Moreover, by 12-months-of-age infants later diagnosed with ASD showed reduced functional connectivity, compared to both infants at low risk for the disorder and infants at high risk who were not later diagnosed with ASD. Significant differences in functional connectivity were also found between low-risk infants and high-risk infants who did not go onto develop ASD. These results demonstrate that reduced functional connectivity appears to be related to genetic vulnerability for ASD. Moreover, they provide further evidence that ASD is broadly characterized by differences in neural integration that emerge during the first year of life.
format	article
author	Giulia Righi Adrienne L Tierney Helen Tager-Flusberg Charles A Nelson
author_facet	Giulia Righi Adrienne L Tierney Helen Tager-Flusberg Charles A Nelson
author_sort	Giulia Righi
title	Functional connectivity in the first year of life in infants at risk for autism spectrum disorder: an EEG study.
title_short	Functional connectivity in the first year of life in infants at risk for autism spectrum disorder: an EEG study.
title_full	Functional connectivity in the first year of life in infants at risk for autism spectrum disorder: an EEG study.
title_fullStr	Functional connectivity in the first year of life in infants at risk for autism spectrum disorder: an EEG study.
title_full_unstemmed	Functional connectivity in the first year of life in infants at risk for autism spectrum disorder: an EEG study.
title_sort	functional connectivity in the first year of life in infants at risk for autism spectrum disorder: an eeg study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1ff9c6b4a8b043668068927ce68c7ee2
work_keys_str_mv	AT giuliarighi functionalconnectivityinthefirstyearoflifeininfantsatriskforautismspectrumdisorderaneegstudy AT adrienneltierney functionalconnectivityinthefirstyearoflifeininfantsatriskforautismspectrumdisorderaneegstudy AT helentagerflusberg functionalconnectivityinthefirstyearoflifeininfantsatriskforautismspectrumdisorderaneegstudy AT charlesanelson functionalconnectivityinthefirstyearoflifeininfantsatriskforautismspectrumdisorderaneegstudy
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Functional connectivity in the first year of life in infants at risk for autism spectrum disorder: an EEG study.

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