Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity

Abstract The purpose of this research was to identify metabolite change during barley (Hordeum vulgare) germination and reveal active principles for the anti-wrinkle activity. Barley was germinated with deionized water (DW) and mineral-rich water (MRW) for the comparison of the effect of mineral con...

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Autores principales:	Sang Cheol Park, Qianwen Wu, Eun-yi Ko, Ji Hwoon Baek, Jeoungjin Ryu, Seunghyun Kang, Mi Kyung Sung, Ah-Reum Cho, Young Pyo Jang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20044d73c08e4404adca6bea4a315fff
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spelling	oai:doaj.org-article:20044d73c08e4404adca6bea4a315fff2021-12-02T15:23:09ZSecondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity10.1038/s41598-020-80322-02045-2322https://doaj.org/article/20044d73c08e4404adca6bea4a315fff2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80322-0https://doaj.org/toc/2045-2322Abstract The purpose of this research was to identify metabolite change during barley (Hordeum vulgare) germination and reveal active principles for the anti-wrinkle activity. Barley was germinated with deionized water (DW) and mineral-rich water (MRW) for the comparison of the effect of mineral contents on the metabolites changes during germination. The effects of germinated barley extracts (GBEs) on collagen production and collagenase inhibition were evaluated in vitro using human dermal fibroblasts (HDFs). A pronounced anti-wrinkle activity was observed in the test group treated with the MRW-GBEs. In order to find out the active components related to the anti-wrinkle activity, an orthogonal projection to latent structure-discriminant analysis (OPLS-DA) was performed, using the data from secondary metabolites profiling conducted by UPLC–PDA–ESI–MS. The anti-wrinkle activity of MRW-GBEs was revealed to be associated with the increase of oligomeric compounds of procyanidin and prodelphinidin, indicating that it can be used as an active ingredient for anti-wrinkle agents.Sang Cheol ParkQianwen WuEun-yi KoJi Hwoon BaekJeoungjin RyuSeunghyun KangMi Kyung SungAh-Reum ChoYoung Pyo JangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sang Cheol Park Qianwen Wu Eun-yi Ko Ji Hwoon Baek Jeoungjin Ryu Seunghyun Kang Mi Kyung Sung Ah-Reum Cho Young Pyo Jang Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity
description	Abstract The purpose of this research was to identify metabolite change during barley (Hordeum vulgare) germination and reveal active principles for the anti-wrinkle activity. Barley was germinated with deionized water (DW) and mineral-rich water (MRW) for the comparison of the effect of mineral contents on the metabolites changes during germination. The effects of germinated barley extracts (GBEs) on collagen production and collagenase inhibition were evaluated in vitro using human dermal fibroblasts (HDFs). A pronounced anti-wrinkle activity was observed in the test group treated with the MRW-GBEs. In order to find out the active components related to the anti-wrinkle activity, an orthogonal projection to latent structure-discriminant analysis (OPLS-DA) was performed, using the data from secondary metabolites profiling conducted by UPLC–PDA–ESI–MS. The anti-wrinkle activity of MRW-GBEs was revealed to be associated with the increase of oligomeric compounds of procyanidin and prodelphinidin, indicating that it can be used as an active ingredient for anti-wrinkle agents.
format	article
author	Sang Cheol Park Qianwen Wu Eun-yi Ko Ji Hwoon Baek Jeoungjin Ryu Seunghyun Kang Mi Kyung Sung Ah-Reum Cho Young Pyo Jang
author_facet	Sang Cheol Park Qianwen Wu Eun-yi Ko Ji Hwoon Baek Jeoungjin Ryu Seunghyun Kang Mi Kyung Sung Ah-Reum Cho Young Pyo Jang
author_sort	Sang Cheol Park
title	Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity
title_short	Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity
title_full	Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity
title_fullStr	Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity
title_full_unstemmed	Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity
title_sort	secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/20044d73c08e4404adca6bea4a315fff
work_keys_str_mv	AT sangcheolpark secondarymetaboliteschangesingerminatedbarleyanditsrelationshiptoantiwrinkleactivity AT qianwenwu secondarymetaboliteschangesingerminatedbarleyanditsrelationshiptoantiwrinkleactivity AT eunyiko secondarymetaboliteschangesingerminatedbarleyanditsrelationshiptoantiwrinkleactivity AT jihwoonbaek secondarymetaboliteschangesingerminatedbarleyanditsrelationshiptoantiwrinkleactivity AT jeoungjinryu secondarymetaboliteschangesingerminatedbarleyanditsrelationshiptoantiwrinkleactivity AT seunghyunkang secondarymetaboliteschangesingerminatedbarleyanditsrelationshiptoantiwrinkleactivity AT mikyungsung secondarymetaboliteschangesingerminatedbarleyanditsrelationshiptoantiwrinkleactivity AT ahreumcho secondarymetaboliteschangesingerminatedbarleyanditsrelationshiptoantiwrinkleactivity AT youngpyojang secondarymetaboliteschangesingerminatedbarleyanditsrelationshiptoantiwrinkleactivity
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Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity

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