In vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties

Numerous compounds derived from natural sources such as microbes, plants, and insects have proven to be safe, efficacious, and cost-effective therapeutics for human diseases. This study examined the bioactivities of propolis, a structural sealant and antibacterial/antifungal agent produced by honey...

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Autores principales:	Abutaha Nael, AL-Zharani Mohammed, Alotaibi Amal, Cordero Mary Anne W., Bepari Asmatanzeem, Alarifi Saud
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	anticancer antimicrobial anti-inflammatory apoptosis propolis Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/200497ac3bb94e50b7974ddf3d101640
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spelling	oai:doaj.org-article:200497ac3bb94e50b7974ddf3d1016402021-12-05T14:10:44ZIn vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties2391-542010.1515/chem-2021-0076https://doaj.org/article/200497ac3bb94e50b7974ddf3d1016402021-08-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0076https://doaj.org/toc/2391-5420Numerous compounds derived from natural sources such as microbes, plants, and insects have proven to be safe, efficacious, and cost-effective therapeutics for human diseases. This study examined the bioactivities of propolis, a structural sealant and antibacterial/antifungal agent produced by honey bees. Chinese propolis was extracted in methanol or hexane. Propolis significantly reduced the numbers of viable cancer cells when applied as a methanol extract (IC50 values in μg/mL for the indicated cell line: MDA-MB-231, 74.12; LoVo, 74.12; HepG2, 77.74; MCF7, 95.10; A549, 114.84) or a hexane extract (MDA-MB-231, 52.11; LoVo, 45.9; HepG2, 52.11; MCF7, 78.01; A549, 67.90). Hexane extract also induced apoptosis of HepG2 cells according to activated caspase-3/7 expression assays (17.6 ± 2.9% at 150 μg/mL and 89.2 ± 1.9% at 300 μg/mL vs 3.4 ± 0.4% in vehicle control), suppressed the growth of Candida albicans and multiple multidrug-resistant and nonresistant Gram-positive bacteria, and inhibited croton oil-induced skin inflammation when applied as topical treatment. GC-MS identified hexadecanoic acid methyl ester as a major constituent (33.6%). Propolis hexane extract has potential anticancer, antimicrobial, and anti-inflammatory activities.Abutaha NaelAL-Zharani MohammedAlotaibi AmalCordero Mary Anne W.Bepari AsmatanzeemAlarifi SaudDe Gruyterarticleanticancerantimicrobialanti-inflammatoryapoptosispropolisChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 864-874 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anticancer antimicrobial anti-inflammatory apoptosis propolis Chemistry QD1-999
spellingShingle	anticancer antimicrobial anti-inflammatory apoptosis propolis Chemistry QD1-999 Abutaha Nael AL-Zharani Mohammed Alotaibi Amal Cordero Mary Anne W. Bepari Asmatanzeem Alarifi Saud In vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties
description	Numerous compounds derived from natural sources such as microbes, plants, and insects have proven to be safe, efficacious, and cost-effective therapeutics for human diseases. This study examined the bioactivities of propolis, a structural sealant and antibacterial/antifungal agent produced by honey bees. Chinese propolis was extracted in methanol or hexane. Propolis significantly reduced the numbers of viable cancer cells when applied as a methanol extract (IC50 values in μg/mL for the indicated cell line: MDA-MB-231, 74.12; LoVo, 74.12; HepG2, 77.74; MCF7, 95.10; A549, 114.84) or a hexane extract (MDA-MB-231, 52.11; LoVo, 45.9; HepG2, 52.11; MCF7, 78.01; A549, 67.90). Hexane extract also induced apoptosis of HepG2 cells according to activated caspase-3/7 expression assays (17.6 ± 2.9% at 150 μg/mL and 89.2 ± 1.9% at 300 μg/mL vs 3.4 ± 0.4% in vehicle control), suppressed the growth of Candida albicans and multiple multidrug-resistant and nonresistant Gram-positive bacteria, and inhibited croton oil-induced skin inflammation when applied as topical treatment. GC-MS identified hexadecanoic acid methyl ester as a major constituent (33.6%). Propolis hexane extract has potential anticancer, antimicrobial, and anti-inflammatory activities.
format	article
author	Abutaha Nael AL-Zharani Mohammed Alotaibi Amal Cordero Mary Anne W. Bepari Asmatanzeem Alarifi Saud
author_facet	Abutaha Nael AL-Zharani Mohammed Alotaibi Amal Cordero Mary Anne W. Bepari Asmatanzeem Alarifi Saud
author_sort	Abutaha Nael
title	In vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties
title_short	In vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties
title_full	In vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties
title_fullStr	In vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties
title_full_unstemmed	In vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties
title_sort	in vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/200497ac3bb94e50b7974ddf3d101640
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In vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties

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