Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys

The off-target effects and on-target mutations of CRISPR editing in higher non-human primates are complex. Here the authors perform whole genome trio sequencing of rhesus monkeys and see no unexpected mutations.

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Autores principales:	Xin Luo, Yaoxi He, Chao Zhang, Xiechao He, Lanzhen Yan, Min Li, Ting Hu, Yan Hu, Jin Jiang, Xiaoyu Meng, Weizhi Ji, Xudong Zhao, Ping Zheng, Shuhua Xu, Bing Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2010f5dcae11485db052f34044756f74
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spelling	oai:doaj.org-article:2010f5dcae11485db052f34044756f742021-12-02T16:57:43ZTrio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys10.1038/s41467-019-13481-y2041-1723https://doaj.org/article/2010f5dcae11485db052f34044756f742019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13481-yhttps://doaj.org/toc/2041-1723The off-target effects and on-target mutations of CRISPR editing in higher non-human primates are complex. Here the authors perform whole genome trio sequencing of rhesus monkeys and see no unexpected mutations.Xin LuoYaoxi HeChao ZhangXiechao HeLanzhen YanMin LiTing HuYan HuJin JiangXiaoyu MengWeizhi JiXudong ZhaoPing ZhengShuhua XuBing SuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin Luo Yaoxi He Chao Zhang Xiechao He Lanzhen Yan Min Li Ting Hu Yan Hu Jin Jiang Xiaoyu Meng Weizhi Ji Xudong Zhao Ping Zheng Shuhua Xu Bing Su Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys
description	The off-target effects and on-target mutations of CRISPR editing in higher non-human primates are complex. Here the authors perform whole genome trio sequencing of rhesus monkeys and see no unexpected mutations.
format	article
author	Xin Luo Yaoxi He Chao Zhang Xiechao He Lanzhen Yan Min Li Ting Hu Yan Hu Jin Jiang Xiaoyu Meng Weizhi Ji Xudong Zhao Ping Zheng Shuhua Xu Bing Su
author_facet	Xin Luo Yaoxi He Chao Zhang Xiechao He Lanzhen Yan Min Li Ting Hu Yan Hu Jin Jiang Xiaoyu Meng Weizhi Ji Xudong Zhao Ping Zheng Shuhua Xu Bing Su
author_sort	Xin Luo
title	Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys
title_short	Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys
title_full	Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys
title_fullStr	Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys
title_full_unstemmed	Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys
title_sort	trio deep-sequencing does not reveal unexpected off-target and on-target mutations in cas9-edited rhesus monkeys
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2010f5dcae11485db052f34044756f74
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Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys

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