Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury

Abstract Growing evidence has shown that gut microbiome is a key factor involved in liver health. Therefore, gut microbiota modulation with probiotic bacteria, such as Saccharomyces boulardii, constitutes a promising therapy for hepatosis. In this study, we aimed to investigate the protective effect...

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Autores principales:	Lei Yu, Xue-ke Zhao, Ming-liang Cheng, Guo-zhen Yang, Bi Wang, Hua-juan Liu, Ya-xin Hu, Li-li Zhu, Shuai Zhang, Zi-wen Xiao, Yong-mei Liu, Bao-fang Zhang, Mao Mu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2011379de5de4b26a8cdaf3193191911
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spelling	oai:doaj.org-article:2011379de5de4b26a8cdaf31931919112021-12-02T11:40:21ZSaccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury10.1038/s41598-017-01271-92045-2322https://doaj.org/article/2011379de5de4b26a8cdaf31931919112017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01271-9https://doaj.org/toc/2045-2322Abstract Growing evidence has shown that gut microbiome is a key factor involved in liver health. Therefore, gut microbiota modulation with probiotic bacteria, such as Saccharomyces boulardii, constitutes a promising therapy for hepatosis. In this study, we aimed to investigate the protective effects of S. boulardii on D-Galactosamine-induced liver injury in mice. Liver function test and histopathological analysis both suggested that the liver injury can be effectively attenuated by S. boulardii administration. In the meantime, S. boulardii induced dramatic changes in the gut microbial composition. At the phylum level, we found that S. boulardii significantly increased in the relative abundance of Bacteroidetes, and decreased the relative abundance of Firmicutes and Proteobacteria, which may explain the hepatic protective effects of S. boulardii. Taken together, our results demonstrated that S. boulardii administration could change the gut microbiota in mice and alleviate acute liver failure, indicating a potential protective and therapeutic role of S. boulardii.Lei YuXue-ke ZhaoMing-liang ChengGuo-zhen YangBi WangHua-juan LiuYa-xin HuLi-li ZhuShuai ZhangZi-wen XiaoYong-mei LiuBao-fang ZhangMao MuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lei Yu Xue-ke Zhao Ming-liang Cheng Guo-zhen Yang Bi Wang Hua-juan Liu Ya-xin Hu Li-li Zhu Shuai Zhang Zi-wen Xiao Yong-mei Liu Bao-fang Zhang Mao Mu Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury
description	Abstract Growing evidence has shown that gut microbiome is a key factor involved in liver health. Therefore, gut microbiota modulation with probiotic bacteria, such as Saccharomyces boulardii, constitutes a promising therapy for hepatosis. In this study, we aimed to investigate the protective effects of S. boulardii on D-Galactosamine-induced liver injury in mice. Liver function test and histopathological analysis both suggested that the liver injury can be effectively attenuated by S. boulardii administration. In the meantime, S. boulardii induced dramatic changes in the gut microbial composition. At the phylum level, we found that S. boulardii significantly increased in the relative abundance of Bacteroidetes, and decreased the relative abundance of Firmicutes and Proteobacteria, which may explain the hepatic protective effects of S. boulardii. Taken together, our results demonstrated that S. boulardii administration could change the gut microbiota in mice and alleviate acute liver failure, indicating a potential protective and therapeutic role of S. boulardii.
format	article
author	Lei Yu Xue-ke Zhao Ming-liang Cheng Guo-zhen Yang Bi Wang Hua-juan Liu Ya-xin Hu Li-li Zhu Shuai Zhang Zi-wen Xiao Yong-mei Liu Bao-fang Zhang Mao Mu
author_facet	Lei Yu Xue-ke Zhao Ming-liang Cheng Guo-zhen Yang Bi Wang Hua-juan Liu Ya-xin Hu Li-li Zhu Shuai Zhang Zi-wen Xiao Yong-mei Liu Bao-fang Zhang Mao Mu
author_sort	Lei Yu
title	Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury
title_short	Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury
title_full	Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury
title_fullStr	Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury
title_full_unstemmed	Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury
title_sort	saccharomyces boulardii administration changes gut microbiota and attenuates d-galactosamine-induced liver injury
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2011379de5de4b26a8cdaf3193191911
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Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury

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