Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy

Hsin-I Chang1, Ming-Kung Yeh21Department of Biochemical Science and Technology, National Chia Yi University, Chiayi City, 2Institute of Preventive Medicine, National Defence Medical Center, Sanhsia, Taipei, TaiwanAbstract: Research on liposome formulations has progressed from that on conventional ve...

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Autores principales:	Chang HI, Yeh MK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2011e8e45ba8406c8ba63568a056f627
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spelling	oai:doaj.org-article:2011e8e45ba8406c8ba63568a056f6272021-12-02T06:31:59ZClinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy1176-91141178-2013https://doaj.org/article/2011e8e45ba8406c8ba63568a056f6272011-12-01T00:00:00Zhttp://www.dovepress.com/clinical-development-of-liposome-based-drugs-formulation-characterizat-a8980https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hsin-I Chang1, Ming-Kung Yeh21Department of Biochemical Science and Technology, National Chia Yi University, Chiayi City, 2Institute of Preventive Medicine, National Defence Medical Center, Sanhsia, Taipei, TaiwanAbstract: Research on liposome formulations has progressed from that on conventional vesicles to new generation liposomes, such as cationic liposomes, temperature sensitive liposomes, and virosomes, by modulating the formulation techniques and lipid composition. Many research papers focus on the correlation of blood circulation time and drug accumulation in target tissues with physicochemical properties of liposomal formulations, including particle size, membrane lamellarity, surface charge, permeability, encapsulation volume, shelf time, and release rate. This review is mainly to compare the therapeutic effect of current clinically approved liposome-based drugs with free drugs, and to also determine the clinical effect via liposomal variations in lipid composition. Furthermore, the major preclinical and clinical data related to the principal liposomal formulations are also summarized.Keywords: PEGlated liposomes, temperature sensitive liposomes, therapeutic efficiency, virosomes, cationic liposomesChang HIYeh MKDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 49-60 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chang HI Yeh MK Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy
description	Hsin-I Chang1, Ming-Kung Yeh21Department of Biochemical Science and Technology, National Chia Yi University, Chiayi City, 2Institute of Preventive Medicine, National Defence Medical Center, Sanhsia, Taipei, TaiwanAbstract: Research on liposome formulations has progressed from that on conventional vesicles to new generation liposomes, such as cationic liposomes, temperature sensitive liposomes, and virosomes, by modulating the formulation techniques and lipid composition. Many research papers focus on the correlation of blood circulation time and drug accumulation in target tissues with physicochemical properties of liposomal formulations, including particle size, membrane lamellarity, surface charge, permeability, encapsulation volume, shelf time, and release rate. This review is mainly to compare the therapeutic effect of current clinically approved liposome-based drugs with free drugs, and to also determine the clinical effect via liposomal variations in lipid composition. Furthermore, the major preclinical and clinical data related to the principal liposomal formulations are also summarized.Keywords: PEGlated liposomes, temperature sensitive liposomes, therapeutic efficiency, virosomes, cationic liposomes
format	article
author	Chang HI Yeh MK
author_facet	Chang HI Yeh MK
author_sort	Chang HI
title	Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy
title_short	Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy
title_full	Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy
title_fullStr	Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy
title_full_unstemmed	Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy
title_sort	clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/2011e8e45ba8406c8ba63568a056f627
work_keys_str_mv	AT changhi clinicaldevelopmentofliposomebaseddrugsformulationcharacterizationandtherapeuticefficacy AT yehmk clinicaldevelopmentofliposomebaseddrugsformulationcharacterizationandtherapeuticefficacy
_version_	1718399862660136960

Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy

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