Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion

The presence of phenotypic heterogeneity in collectively invading cells suggests cooperation amongst distinct subtypes of cells to promote invasion and metastasis. Here, the authors use chemical biology tools and report metabolic heterogeneity within the lung cancer collective invasion pack.

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Autores principales:	R. Commander, C. Wei, A. Sharma, J. K. Mouw, L. J. Burton, E. Summerbell, D. Mahboubi, R. J. Peterson, J. Konen, W. Zhou, Y. Du, H. Fu, M. Shanmugam, A. I. Marcus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/201390d98d734e01bdb1147f679e4c86
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spelling	oai:doaj.org-article:201390d98d734e01bdb1147f679e4c862021-12-02T14:42:31ZSubpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion10.1038/s41467-020-15219-72041-1723https://doaj.org/article/201390d98d734e01bdb1147f679e4c862020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15219-7https://doaj.org/toc/2041-1723The presence of phenotypic heterogeneity in collectively invading cells suggests cooperation amongst distinct subtypes of cells to promote invasion and metastasis. Here, the authors use chemical biology tools and report metabolic heterogeneity within the lung cancer collective invasion pack.R. CommanderC. WeiA. SharmaJ. K. MouwL. J. BurtonE. SummerbellD. MahboubiR. J. PetersonJ. KonenW. ZhouY. DuH. FuM. ShanmugamA. I. MarcusNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q R. Commander C. Wei A. Sharma J. K. Mouw L. J. Burton E. Summerbell D. Mahboubi R. J. Peterson J. Konen W. Zhou Y. Du H. Fu M. Shanmugam A. I. Marcus Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion
description	The presence of phenotypic heterogeneity in collectively invading cells suggests cooperation amongst distinct subtypes of cells to promote invasion and metastasis. Here, the authors use chemical biology tools and report metabolic heterogeneity within the lung cancer collective invasion pack.
format	article
author	R. Commander C. Wei A. Sharma J. K. Mouw L. J. Burton E. Summerbell D. Mahboubi R. J. Peterson J. Konen W. Zhou Y. Du H. Fu M. Shanmugam A. I. Marcus
author_facet	R. Commander C. Wei A. Sharma J. K. Mouw L. J. Burton E. Summerbell D. Mahboubi R. J. Peterson J. Konen W. Zhou Y. Du H. Fu M. Shanmugam A. I. Marcus
author_sort	R. Commander
title	Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion
title_short	Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion
title_full	Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion
title_fullStr	Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion
title_full_unstemmed	Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion
title_sort	subpopulation targeting of pyruvate dehydrogenase and glut1 decouples metabolic heterogeneity during collective cancer cell invasion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/201390d98d734e01bdb1147f679e4c86
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Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion

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