Attention-based multi-label neural networks for integrated prediction and interpretation of twelve widely occurring RNA modifications

RNA modifications appear to play a role in determining RNA structure and function. Here, the authors develop a deep learning model that predicts the location of 12 RNA modifications using primary sequence, and show that several modifications are associated, which suggests dependencies between them.

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Detalles Bibliográficos
Autores principales: Zitao Song, Daiyun Huang, Bowen Song, Kunqi Chen, Yiyou Song, Gang Liu, Jionglong Su, João Pedro de Magalhães, Daniel J. Rigden, Jia Meng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2013910e98b9461eaf0247a35dedc43a
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Sumario:RNA modifications appear to play a role in determining RNA structure and function. Here, the authors develop a deep learning model that predicts the location of 12 RNA modifications using primary sequence, and show that several modifications are associated, which suggests dependencies between them.