Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice

Sarcolipin is an inhibitor of the ATP dependent calcium pump SERCA, and is abnormally elevated in Duchenne muscular dystrophy. The authors show that reducing sarcolipin expression ameliorates skeletal muscle pathology and cardiomyopathy and extends life span in mouse models of DMD.

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Autores principales:	Antanina Voit, Vishwendra Patel, Ronald Pachon, Vikas Shah, Mohammad Bakhutma, Erik Kohlbrenner, Joseph J. McArdle, Louis J. Dell’Italia, Jerry R. Mendell, Lai-Hua Xie, Roger J. Hajjar, Dongsheng Duan, Diego Fraidenraich, Gopal J. Babu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/201501e20c1241caab7a1010c329171a
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spelling	oai:doaj.org-article:201501e20c1241caab7a1010c329171a2021-12-02T14:42:02ZReducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice10.1038/s41467-017-01146-72041-1723https://doaj.org/article/201501e20c1241caab7a1010c329171a2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01146-7https://doaj.org/toc/2041-1723Sarcolipin is an inhibitor of the ATP dependent calcium pump SERCA, and is abnormally elevated in Duchenne muscular dystrophy. The authors show that reducing sarcolipin expression ameliorates skeletal muscle pathology and cardiomyopathy and extends life span in mouse models of DMD.Antanina VoitVishwendra PatelRonald PachonVikas ShahMohammad BakhutmaErik KohlbrennerJoseph J. McArdleLouis J. Dell’ItaliaJerry R. MendellLai-Hua XieRoger J. HajjarDongsheng DuanDiego FraidenraichGopal J. BabuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antanina Voit Vishwendra Patel Ronald Pachon Vikas Shah Mohammad Bakhutma Erik Kohlbrenner Joseph J. McArdle Louis J. Dell’Italia Jerry R. Mendell Lai-Hua Xie Roger J. Hajjar Dongsheng Duan Diego Fraidenraich Gopal J. Babu Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice
description	Sarcolipin is an inhibitor of the ATP dependent calcium pump SERCA, and is abnormally elevated in Duchenne muscular dystrophy. The authors show that reducing sarcolipin expression ameliorates skeletal muscle pathology and cardiomyopathy and extends life span in mouse models of DMD.
format	article
author	Antanina Voit Vishwendra Patel Ronald Pachon Vikas Shah Mohammad Bakhutma Erik Kohlbrenner Joseph J. McArdle Louis J. Dell’Italia Jerry R. Mendell Lai-Hua Xie Roger J. Hajjar Dongsheng Duan Diego Fraidenraich Gopal J. Babu
author_facet	Antanina Voit Vishwendra Patel Ronald Pachon Vikas Shah Mohammad Bakhutma Erik Kohlbrenner Joseph J. McArdle Louis J. Dell’Italia Jerry R. Mendell Lai-Hua Xie Roger J. Hajjar Dongsheng Duan Diego Fraidenraich Gopal J. Babu
author_sort	Antanina Voit
title	Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice
title_short	Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice
title_full	Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice
title_fullStr	Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice
title_full_unstemmed	Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice
title_sort	reducing sarcolipin expression mitigates duchenne muscular dystrophy and associated cardiomyopathy in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/201501e20c1241caab7a1010c329171a
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Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice

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